Q32PQ5 · Q32PQ5_DANRE

Function

function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentmelanosome
Molecular Functiontransferrin receptor activity
Biological Processhemoglobin biosynthetic process
Biological Processintracellular iron ion homeostasis
Biological Processiron ion transport
Biological Processreceptor internalization
Biological Processtransferrin transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Transferrin receptor protein 1

Gene names

    • Name
      tfr1b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q32PQ5

Proteomes

    • Identifier
    • Component
      Alternate scaffold 24, Chromosome 24

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Melanosome
Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane78-99Helical

Keywords

PTM/Processing

Post-translational modification

Stearoylated.

Keywords

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias103-118Basic and acidic residues
Region103-128Disordered
Domain234-297PA
Domain394-590Peptidase M28

Sequence similarities

Belongs to the peptidase M28 family. M28B subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    771
  • Mass (Da)
    85,354
  • Last updated
    2005-12-06 v1
  • Checksum
    28BA8427E772736D
MAGTIGQAKMKFSRMVNSRSYSRFNQSQNPDGDGSRVEVKLAVDGEEEEMDGTELGNMQQETYTRSTGRSEPLNKYRILVCVGAALLVFLVGLLIGYSVHRKSDNKSEPLETPCSKEIQAEEPDPPQYEPIVPSIDWSDIVKLLNDKLSSKSIEEQLSVYSQIGRSAGSSVDNKLGDTIHDAFTKLNMEPWVDEHYVKLQNPDSSNPNKVWFGNEEIGSPKGFLAYSETGRREGRVVYANYGEPADLQAVQANEVSLNGTVVLMRAGRISMAQKVMNVAKLGAVAALIYPDPANYDGMDTELYGHVHLGSGDPYTPGFPSFNHTQFAPAKSSGLPEILAQTIPASMARKILSKMGGSEVPSKFKGGFTSYKFGDESNKVALSINNKLVDTKIHNVFGVIKGYVDPDRYVVIGAQRDSMTSGYAKSAVGTTLLMELARVFNELKKEGFKPKRSIVFASWTAGDFGKVGATEWLEGYWASLDRKAFTYISLDGVVSGKDSLRASASPLLHTLLQKTLEKVKAPMLSYGSDFSSILTNMQMDDGAYPFLTFSGIPSVSFSFISSRTTPDYKYFGTEMDTKERLDSVTGQQVVELSMLAAQVAGQMALRLVHDQILRLDVTKYGGVIESHVKNIIHHVNVLKSEKVEKIETLSTEWLIAAKSSCSRAATKLNNDIKNSDLEDMEMCRIINNRIMKVEHNFLSPYVSIRDFPFRHIFFGNGWQTATDLENYLQDVRDKKASFDIDQVLNKFALLTWSIQGCANDLAGDIWSLDNEI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias103-118Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC108025
EMBL· GenBank· DDBJ
AAI08026.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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