Q32PI8 · RT27_BOVIN
- ProteinSmall ribosomal subunit protein mS27
- GeneMRPS27
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids415 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial small ribosomal subunit | |
Cellular Component | mitochondrion | |
Molecular Function | mitochondrial ribosome binding | |
Molecular Function | rRNA binding | |
Molecular Function | tRNA binding | |
Biological Process | cell population proliferation | |
Biological Process | positive regulation of mitochondrial translation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein mS27
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ32PI8
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-8 | Mitochondrion | ||||
Sequence: MAAPMVRR | ||||||
Chain | PRO_0000261585 | 9-415 | Small ribosomal subunit protein mS27 | |||
Sequence: AIFLARNVLLPQLSLAGKRYLLSAAYEDSRKWEARAKEDCHLADLASLMDKTYERKLPVSSLTISRFVDNISSREEIDHAEYYLYKFRHSPNCWYLRNWTIHTWIRQCLKYGAQDKALYTLVNKVQYGIFPDNYTFNLLMDHFIKKENYKDALSVVFEIMMQEAFEVPSTQLLSLYVLYQCLAKKTDFSWEEERNFGASLLLPGLKQKNSVGLSSQLYGYALLGKVELQQGLRAVYHNMPLLWRPGYLDRALQVMEKVASSPEDGKLCREALGVLDRALKALTAPAQESPEEQPQEGEESPASEELMEQLDVEETEQSKLPRYVERYEALHSKLQALGKVESESLLTLTTQLVKEQLPTCEAEDIATYEQKLQEWHLELVNLIEREKEMREKARLKHEARRAAKAAA |
Proteomic databases
Interaction
Subunit
Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (PubMed:11344316).
Interacts with NOA1 (By similarity).
Interacts with MIEF1 upstream open reading frame protein (By similarity).
Interacts with METTL17 (By similarity).
Interacts with NOA1 (By similarity).
Interacts with MIEF1 upstream open reading frame protein (By similarity).
Interacts with METTL17 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 105-139 | PPR 1 | ||||
Sequence: RNWTIHTWIRQCLKYGAQDKALYTLVNKVQYGIFP | ||||||
Repeat | 140-175 | PPR 2 | ||||
Sequence: DNYTFNLLMDHFIKKENYKDALSVVFEIMMQEAFEV | ||||||
Region | 292-325 | Disordered | ||||
Sequence: APAQESPEEQPQEGEESPASEELMEQLDVEETEQ | ||||||
Compositional bias | 300-319 | Acidic residues | ||||
Sequence: EQPQEGEESPASEELMEQLD | ||||||
Coiled coil | 368-415 | |||||
Sequence: CEAEDIATYEQKLQEWHLELVNLIEREKEMREKARLKHEARRAAKAAA |
Sequence similarities
Belongs to the mitochondrion-specific ribosomal protein mS27 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length415
- Mass (Da)47,955
- Last updated2005-12-06 v1
- ChecksumAC765A6DBE9A9296
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 201-202 | in Ref. 2; AA sequence | ||||
Sequence: ER → RN | ||||||
Compositional bias | 300-319 | Acidic residues | ||||
Sequence: EQPQEGEESPASEELMEQLD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC108100 EMBL· GenBank· DDBJ | AAI08101.1 EMBL· GenBank· DDBJ | mRNA |