Q32NN2 · QKIA_XENLA
- ProteinKH domain-containing RNA-binding protein qki.S
- Geneqki.S
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids341 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (By similarity).
Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity).
Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N7-methylguanine (m7G) (By similarity).
Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity).
Acts as an important regulator of muscle development (By similarity).
Essential for notochord development (PubMed:9303534).
Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity).
Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N7-methylguanine (m7G) (By similarity).
Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity).
Acts as an important regulator of muscle development (By similarity).
Essential for notochord development (PubMed:9303534).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | identical protein binding | |
Molecular Function | poly(U) RNA binding | |
Molecular Function | single-stranded RNA binding | |
Biological Process | mRNA transport | |
Biological Process | negative regulation of macrophage differentiation | |
Biological Process | notochord cell differentiation | |
Biological Process | notochord development | |
Biological Process | notochord formation | |
Biological Process | regulation of astrocyte differentiation | |
Biological Process | regulation of translation | |
Biological Process | spliceosome-depend formation of circular RNA |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameKH domain-containing RNA-binding protein qki.S
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ32NN2
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000239380 | 1-341 | KH domain-containing RNA-binding protein qki.S | |||
Sequence: MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFTHLERLLDEEISRVRKDMYNDTMNSSSNEKRTSELPDGIGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDAQNRAELKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANLKSPALAFSLAATGQAPRIITGPAPVLSPAALRTPTPAGHTLMPLIRQIQTAVMPNGTPHPTATLMQQAPEGGLIYTPYEYPYTLAPATSILEYPIEASGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN |
Expression
Developmental stage
First detected in the chordamesoderm of the dorsal blastopore lip of the mid-gastrula embryo (stage 11). This tissue, which differentiates into the notochord. In late gastrula embryos (stage 13), it is highly expressed in the notochord, and the original expression domain expands to include the tissue surrounding the blastopore. In neurula embryos, it is maintained in the notochord and the circumblastoporal region and now also extends to the paraxial mesoderm and the neuroectoderm. By the tailbud stage, it is expressed in various mesodermal and neural tissues. Highly expressed in the brain and the neural tube. Maintained throughout development to the tadpole stage (stage 35).
Gene expression databases
Interaction
Subunit
Homodimer; does not require RNA to homodimerize.
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 88-154 | KH | ||||
Sequence: YVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHV | ||||||
Motif | 324-330 | Nuclear localization signal | ||||
Sequence: RVHPYQR |
Sequence similarities
Belongs to the quaking family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q32NN2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length341
- Mass (Da)37,879
- Last updated2006-06-13 v2
- ChecksumF39F36CB80DE77A1
Q32NN2-2
- Name2
- SynonymsXqua365
- Differences from canonical
- 1-1: M → MFFGHAGCDIRNSAAPAFGLFDWNM
Q32NN2-3
- Name3
- SynonymsXqua357
Q32NN2-4
- Name4
- Differences from canonical
- 214-221: Missing
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J1KRR9 | A0A8J1KRR9_XENLA | qki.S | 379 | ||
A0A8J1KRN5 | A0A8J1KRN5_XENLA | qki.S | 342 | ||
A0A1L8G2F2 | A0A1L8G2F2_XENLA | qki.S | 365 | ||
A0A8J0VEW5 | A0A8J0VEW5_XENLA | qki.S | 380 | ||
A0A8J0VEX0 | A0A8J0VEX0_XENLA | qki.S | 358 | ||
A0A8J0VE05 | A0A8J0VE05_XENLA | qki.S | 372 | ||
A0A8J0VJC2 | A0A8J0VJC2_XENLA | qki.S | 343 |
Features
Showing features for alternative sequence, sequence conflict.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC108554 EMBL· GenBank· DDBJ | AAI08555.1 EMBL· GenBank· DDBJ | mRNA |