DNA double-strand breaks induce H2Ax phosphorylation domains in a contact- dependent manner.Collins P.L., Purman C., Porter S.I., Nganga V., Saini A., Hayer K.E., Gurewitz G.L., Sleckman B.P., Bednarski J.J.[...], Oltz E.M.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCNat Commun 11:3158-3158 (2020)Mapped to5
CtIP is essential for early B cell proliferation and development in mice.Liu X., Wang X.S., Lee B.J., Wu-Baer F.K., Lin X., Shao Z., Estes V.M., Gautier J., Baer R., Zha S.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCJ Exp Med 216:1648-1663 (2019)Mapped to12
MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene- Induced Replication Stress.Spehalski E., Capper K.M., Smith C.J., Morgan M.J., Dinkelmann M., Buis J., Sekiguchi J.M., Ferguson D.O.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCCancer Res 77:5327-5338 (2017)Mapped to35
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.Jiang W., Crowe J.L., Liu X., Nakajima S., Wang Y., Li C., Lee B.J., Dubois R.L., Liu C.[...], Zha S.View abstractAnnotationATM phosphorylates DNA-PKcs to recruit Artemis and promote end-processing.CategoriesFunctionSourceGeneRif: 227525, MGI: 2441769PubMedEurope PMCMol Cell 58:172-185 (2015)Mapped to44
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.Makharashvili N., Tubbs A.T., Yang S.H., Wang H., Barton O., Zhou Y., Deshpande R.A., Lee J.H., Lobrich M.[...], Paull T.T.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCMol Cell 54:1022-1033 (2014)Mapped to13
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.Chan E.A., Teng G., Corbett E., Choudhury K.R., Bassing C.H., Schatz D.G., Krangel M.S.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCProc Natl Acad Sci U S A 110:E4628-37 (2013)Mapped to26
Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency.Barthels C., Puchalka J., Racek T., Klein C., Brocker T.View abstractAnnotationwe present T(-)B(-)NK(+) severe combined immunodeficiency (SCID) phenotype after spontaneously occurring modification of Artemis gene in mice.CategoriesSequences, Phenotypes & VariantsSourceGeneRif: 227525, MGI: 2441769PubMedEurope PMCPLoS One 8:e74838-e74838 (2013)Mapped to4
Opposing roles for 53BP1 during homologous recombination.Kakarougkas A., Ismail A., Klement K., Goodarzi A.A., Conrad S., Freire R., Shibata A., Lobrich M., Jeggo P.A.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCNucleic Acids Res 41:9719-9731 (2013)Mapped to38
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.Lee B.S., Gapud E.J., Zhang S., Dorsett Y., Bredemeyer A., George R., Callen E., Daniel J.A., Osipovich O.[...], Sleckman B.P.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCMol Cell Biol 33:3568-3579 (2013)Mapped to13
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.Oksenych V., Kumar V., Liu X., Guo C., Schwer B., Zha S., Alt F.W.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCProc Natl Acad Sci U S A 110:2234-2239 (2013)Mapped to20
Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans.Vera G., Rivera-Munoz P., Abramowski V., Malivert L., Lim A., Bole-Feysot C., Martin C., Florkin B., Latour S.[...], de Villartay J.P.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCMol Cell Biol 33:701-711 (2013)Mapped to24
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.Bednarski J.J., Nickless A., Bhattacharya D., Amin R.H., Schlissel M.S., Sleckman B.P.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCJ Exp Med 209:11-17 (2012)Mapped to16
Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.Woodbine L., Brunton H., Goodarzi A.A., Shibata A., Jeggo P.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2441769PubMedEurope PMCNucleic Acids Res 39:6986-6997 (2011)Mapped to15
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.Diez-Roux G., Banfi S., Sultan M., Geffers L., Anand S., Rozado D., Magen A., Canidio E., Pagani M.[...], Ballabio A.View abstractCategoriesExpressionSourceMGI: 2441769PubMedEurope PMCPLoS Biol 9:e1000582-e1000582 (2011)Mapped to99+
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1- phase lymphocytes.Helmink B.A., Tubbs A.T., Dorsett Y., Bednarski J.J., Walker L.M., Feng Z., Sharma G.G., McKinnon P.J., Zhang J.[...], Sleckman B.P.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCNature 469:245-249 (2011)Mapped to14
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis.Jacobs C., Huang Y., Masud T., Lu W., Westfield G., Giblin W., Sekiguchi J.M.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 2441769PubMedEurope PMCHum Mol Genet 20:806-819 (2011)Mapped to24
ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells.Maas S.A., Donghia N.M., Tompkins K., Foreman O., Mills K.D.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCBMC Biol 8:132-132 (2010)Mapped to18
Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.Yin B., Yang-Iott K.S., Chao L.H., Bassing C.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 2441769PubMedEurope PMCBlood 117:175-185 (2011)Mapped to19
Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes.Singh P., Alley T.L., Wright S.M., Kamdar S., Schott W., Wilpan R.Y., Mills K.D., Graber J.H.View abstractCategoriesSequences, ExpressionSourceMGI: 2441769PubMedEurope PMCCancer Res 69:9422-9430 (2009)Mapped to18
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.Yin B., Savic V., Juntilla M.M., Bredemeyer A.L., Yang-Iott K.S., Helmink B.A., Koretzky G.A., Sleckman B.P., Bassing C.H.View abstractCategoriesFunction, PTM / ProcessingSourceMGI: 2441769PubMedEurope PMCJ Exp Med 206:2625-2639 (2009)Mapped to19
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.Beucher A., Birraux J., Tchouandong L., Barton O., Shibata A., Conrad S., Goodarzi A.A., Krempler A., Jeggo P.A., Lobrich M.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCEMBO J 28:3413-3427 (2009)Mapped to15
Reduced immunoglobulin class switch recombination in the absence of Artemis.Rivera-Munoz P., Soulas-Sprauel P., Le Guyader G., Abramowski V., Bruneau S., Fischer A., Paques F., de Villartay J.P.View abstractAnnotationLoss of Artemis leads to reduced immunoglobulin class switch recombination.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 227525, MGI: 2441769PubMedEurope PMCBlood 114:3601-3609 (2009)Mapped to13
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.Savic V., Yin B., Maas N.L., Bredemeyer A.L., Carpenter A.C., Helmink B.A., Yang-Iott K.S., Sleckman B.P., Bassing C.H.View abstractCategoriesFunction, PTM / Processing, InteractionSourceMGI: 2441769PubMedEurope PMCMol Cell 34:298-310 (2009)Mapped to33
Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes.Wright S.M., Woo Y.H., Alley T.L., Shirley B.J., Akeson E.C., Snow K.J., Maas S.A., Elwell R.L., Foreman O., Mills K.D.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCCancer Res 69:4454-4460 (2009)Mapped to19
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.Deriano L., Stracker T.H., Baker A., Petrini J.H., Roth D.B.View abstractCategoriesFunctionSourceMGI: 2441769PubMedEurope PMCMol Cell 34:13-25 (2009)Mapped to11