Q32MU4 · Q32MU4_MOUSE
- ProteinTransporter
- GeneSlc6a4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids630 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- H+(in) + K+(in) + Na+(out) + serotonin(out) = H+(out) + K+(out) + Na+(in) + serotonin(in)This reaction proceeds in the forward direction.H+ (in)CHEBI:15378
+ K+ (in)CHEBI:29103+ Na+ (out)CHEBI:29101+ serotonin (out)CHEBI:350546= H+ (out)CHEBI:15378+ K+ (out)CHEBI:29103+ Na+ (in)CHEBI:29101+ serotonin (in)CHEBI:350546
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 94 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 96 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 97 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 101 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 336 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 368 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 434 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 437 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 438 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | focal adhesion | |
Cellular Component | neuron projection | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Molecular Function | antiporter activity | |
Molecular Function | metal ion binding | |
Molecular Function | serotonin:sodium:chloride symporter activity | |
Biological Process | regulation of thalamus size |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransporter
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ32MU4
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endomembrane system ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 88-106 | Helical | ||||
Sequence: FLLSVIGYAVDLGNIWRFP | ||||||
Transmembrane | 118-139 | Helical | ||||
Sequence: LLPYTIMAIFGGIPLFYMELAL | ||||||
Transmembrane | 160-188 | Helical | ||||
Sequence: GIGYAICIIAFYIASYYNTIIAWALYYLI | ||||||
Transmembrane | 251-268 | Helical | ||||
Sequence: ISWQLALCIMLIFTIIYF | ||||||
Transmembrane | 280-306 | Helical | ||||
Sequence: VVWVTATFPYIVLSVLLVRGATLPGAW | ||||||
Transmembrane | 326-350 | Helical | ||||
Sequence: WVDAAAQIFFSLGPGFGVLLAFASY | ||||||
Transmembrane | 362-387 | Helical | ||||
Sequence: LVTSVVNCMTSFVSGFVIFTVLGYMA | ||||||
Transmembrane | 422-443 | Helical | ||||
Sequence: FFAIIFFLMLITLGLDSTFAGL | ||||||
Transmembrane | 464-488 | Helical | ||||
Sequence: WFVLIVVITCILGSLLTLTSGGAYV | ||||||
Transmembrane | 500-523 | Helical | ||||
Sequence: AVLTVALIEAVVVSWFYGITQFCS | ||||||
Transmembrane | 535-558 | Helical | ||||
Sequence: WFWRICWVAISPLFLLFIICSFLM | ||||||
Transmembrane | 570-595 | Helical | ||||
Sequence: YPHWSIILGYCIGTSSVICIPIYIIY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 200↔209 | |||||
Sequence: CKNSWNTGNC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-63 | Disordered | ||||
Sequence: METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAEPGQISNGYSAVPSTSAGDEAPHST | ||||||
Domain | 24-64 | Sodium:neurotransmitter symporter serotonin N-terminal | ||||
Sequence: NGVLQKGVPTPADKAEPGQISNGYSAVPSTSAGDEAPHSTP | ||||||
Compositional bias | 45-63 | Polar residues | ||||
Sequence: NGYSAVPSTSAGDEAPHST |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length630
- Mass (Da)70,148
- Last updated2005-12-06 v1
- ChecksumF37EF1EC1764FB30
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 45-63 | Polar residues | ||||
Sequence: NGYSAVPSTSAGDEAPHST |