Q32MQ0 · ZN750_HUMAN
- ProteinZinc finger protein 750
- GeneZNF750
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids723 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | promoter-specific chromatin binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | cell differentiation | |
Biological Process | epidermis development | |
Biological Process | establishment of skin barrier | |
Biological Process | membrane biogenesis | |
Biological Process | negative regulation of epithelial to mesenchymal transition | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of ceramide biosynthetic process | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 750
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ32MQ0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Seborrhea-like dermatitis with psoriasiform elements (SLDP)
- Note
- DescriptionCharacterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.
- See alsoMIM:610227
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 27 | Abolishes the ability to induce epidermal terminal differentiation; when associated with A-30. | ||||
Sequence: C → A | ||||||
Mutagenesis | 30 | Abolishes the ability to induce epidermal terminal differentiation; when associated with A-27. | ||||
Sequence: C → A | ||||||
Mutagenesis | 34 | Retains the ability to bind zinc; when associated with A-39. | ||||
Sequence: C → A | ||||||
Mutagenesis | 39 | Abolishes the ability to induce epidermal terminal differentiation; when associated with A-43. Retains the ability to bind zinc; when associated with A-34. | ||||
Sequence: H → A | ||||||
Mutagenesis | 43 | Abolishes the ability to induce epidermal terminal differentiation; when associated with A-39. | ||||
Sequence: H → A | ||||||
Natural variant | VAR_027062 | 235 | in dbSNP:rs8074277 | |||
Sequence: M → V | ||||||
Natural variant | VAR_051502 | 288 | in dbSNP:rs35653278 | |||
Sequence: P → L | ||||||
Natural variant | VAR_051503 | 392 | in dbSNP:rs34687659 | |||
Sequence: Q → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 913 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000247070 | 1-723 | UniProt | Zinc finger protein 750 | |||
Sequence: MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITLVSEQDRVPKCPKSNSLDPKQTNQPDATAKPASSKSVANGLSAFDSKLQHSSAREDIKENLELQARGTHRCLGQKPALHRASPCKSPAPEAALGAQPALEGAARPSAFVPVGEHRLKGPDNAEAPETLALHNPTAKAVSFHTKSAFHTPGYPWKAGSPFLPPEFPHKISSTKGLGAISPYMHPTIPEYPPHFYTEHGLATIYSPYLLAGSSPECDAPLLSVYGTQDPRHFLPHPGPIPKHLAPSPATYDHYRFFQQYPSNLPIPYGFYRPESAFSSYGLRLPPVTGLTRDQSSHLLEEATLVYPASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAGQRDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTCEGLYDLSNKAASSALGRLYPPEQSLTAFRPVKKSTECLPAQAAETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPCNTQAPRPAFPGRPRAAEPAAAVPQKTGTEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAVDSSEEQKQTAAVALCQLAAYSPRNIRVGDGDAAAPEPACRQDTPTLSSMESQEAQCDLRPKGQKRTSLRDAGKSQQGAKKAKLQDTARVFTLRRRARVS | |||||||
Modified residue (large scale data) | 136 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 140 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.
Induction
During epidermal differentiation: expression is activated by p63/TP63.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q32MQ0 | CTBP2 P56545 | 3 | EBI-10240029, EBI-741533 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 25-51 | CCHC-type | ||||
Sequence: YKCFQCPFTCNEKSHLFNHMKYGLCKN | ||||||
Region | 64-91 | Disordered | ||||
Sequence: KCPKSNSLDPKQTNQPDATAKPASSKSV | ||||||
Compositional bias | 69-91 | Polar residues | ||||
Sequence: NSLDPKQTNQPDATAKPASSKSV | ||||||
Region | 132-153 | Disordered | ||||
Sequence: LHRASPCKSPAPEAALGAQPAL | ||||||
Region | 359-427 | Disordered | ||||
Sequence: ASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAGQRDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTC | ||||||
Compositional bias | 369-393 | Basic and acidic residues | ||||
Sequence: DPNRKHVEFESPIPEAKDSSKAGQR | ||||||
Compositional bias | 411-427 | Polar residues | ||||
Sequence: SPGRPSPTDFMQTSQTC | ||||||
Compositional bias | 466-480 | Polar residues | ||||
Sequence: PAQAAETTAESPVSL | ||||||
Region | 466-630 | Disordered | ||||
Sequence: PAQAAETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPCNTQAPRPAFPGRPRAAEPAAAVPQKTGTEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAVDSSEEQ | ||||||
Compositional bias | 496-559 | Polar residues | ||||
Sequence: LVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPC | ||||||
Region | 650-723 | Disordered | ||||
Sequence: RVGDGDAAAPEPACRQDTPTLSSMESQEAQCDLRPKGQKRTSLRDAGKSQQGAKKAKLQDTARVFTLRRRARVS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length723
- Mass (Da)77,361
- Last updated2005-12-06 v1
- Checksum890E7DB46DD0F5FF
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
I3L0W7 | I3L0W7_HUMAN | ZNF750 | 324 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 69-91 | Polar residues | ||||
Sequence: NSLDPKQTNQPDATAKPASSKSV | ||||||
Sequence conflict | 178 | in Ref. 1; BAB14718 | ||||
Sequence: A → P | ||||||
Compositional bias | 369-393 | Basic and acidic residues | ||||
Sequence: DPNRKHVEFESPIPEAKDSSKAGQR | ||||||
Compositional bias | 411-427 | Polar residues | ||||
Sequence: SPGRPSPTDFMQTSQTC | ||||||
Compositional bias | 466-480 | Polar residues | ||||
Sequence: PAQAAETTAESPVSL | ||||||
Compositional bias | 496-559 | Polar residues | ||||
Sequence: LVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPC |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK023903 EMBL· GenBank· DDBJ | BAB14718.1 EMBL· GenBank· DDBJ | mRNA | ||
AC068584 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC109036 EMBL· GenBank· DDBJ | AAI09037.1 EMBL· GenBank· DDBJ | mRNA | ||
BC109037 EMBL· GenBank· DDBJ | AAI09038.1 EMBL· GenBank· DDBJ | mRNA |