Q32MQ0 · ZN750_HUMAN

  • Protein
    Zinc finger protein 750
  • Gene
    ZNF750
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.

Features

Showing features for binding site.

1723100200300400500600700
TypeIDPosition(s)Description
Binding site27Zn2+ (UniProtKB | ChEBI)
Binding site30Zn2+ (UniProtKB | ChEBI)
Binding site43Zn2+ (UniProtKB | ChEBI)
Binding site49Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular Functionpromoter-specific chromatin binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processcell differentiation
Biological Processepidermis development
Biological Processestablishment of skin barrier
Biological Processmembrane biogenesis
Biological Processnegative regulation of epithelial to mesenchymal transition
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of ceramide biosynthetic process
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 750

Gene names

    • Name
      ZNF750

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q32MQ0
  • Secondary accessions
    • Q9H899

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Involvement in disease

Seborrhea-like dermatitis with psoriasiform elements (SLDP)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    Characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.
  • See also
    MIM:610227

Features

Showing features for mutagenesis, natural variant.

TypeIDPosition(s)Description
Mutagenesis27Abolishes the ability to induce epidermal terminal differentiation; when associated with A-30.
Mutagenesis30Abolishes the ability to induce epidermal terminal differentiation; when associated with A-27.
Mutagenesis34Retains the ability to bind zinc; when associated with A-39.
Mutagenesis39Abolishes the ability to induce epidermal terminal differentiation; when associated with A-43. Retains the ability to bind zinc; when associated with A-34.
Mutagenesis43Abolishes the ability to induce epidermal terminal differentiation; when associated with A-39.
Natural variantVAR_027062235in dbSNP:rs8074277
Natural variantVAR_051502288in dbSNP:rs35653278
Natural variantVAR_051503392in dbSNP:rs34687659

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 913 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002470701-723UniProtZinc finger protein 750
Modified residue (large scale data)136PRIDEPhosphoserine
Modified residue (large scale data)140PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.

Induction

During epidermal differentiation: expression is activated by p63/TP63.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q32MQ0CTBP2 P565453EBI-10240029, EBI-741533

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger25-51CCHC-type
Region64-91Disordered
Compositional bias69-91Polar residues
Region132-153Disordered
Region359-427Disordered
Compositional bias369-393Basic and acidic residues
Compositional bias411-427Polar residues
Compositional bias466-480Polar residues
Region466-630Disordered
Compositional bias496-559Polar residues
Region650-723Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    723
  • Mass (Da)
    77,361
  • Last updated
    2005-12-06 v1
  • Checksum
    890E7DB46DD0F5FF
MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHLFNHMKYGLCKNSITLVSEQDRVPKCPKSNSLDPKQTNQPDATAKPASSKSVANGLSAFDSKLQHSSAREDIKENLELQARGTHRCLGQKPALHRASPCKSPAPEAALGAQPALEGAARPSAFVPVGEHRLKGPDNAEAPETLALHNPTAKAVSFHTKSAFHTPGYPWKAGSPFLPPEFPHKISSTKGLGAISPYMHPTIPEYPPHFYTEHGLATIYSPYLLAGSSPECDAPLLSVYGTQDPRHFLPHPGPIPKHLAPSPATYDHYRFFQQYPSNLPIPYGFYRPESAFSSYGLRLPPVTGLTRDQSSHLLEEATLVYPASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAGQRDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTCEGLYDLSNKAASSALGRLYPPEQSLTAFRPVKKSTECLPAQAAETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDSSGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQDLPLNLSVKDPCNTQAPRPAFPGRPRAAEPAAAVPQKTGTEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAVDSSEEQKQTAAVALCQLAAYSPRNIRVGDGDAAAPEPACRQDTPTLSSMESQEAQCDLRPKGQKRTSLRDAGKSQQGAKKAKLQDTARVFTLRRRARVS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
I3L0W7I3L0W7_HUMANZNF750324

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias69-91Polar residues
Sequence conflict178in Ref. 1; BAB14718
Compositional bias369-393Basic and acidic residues
Compositional bias411-427Polar residues
Compositional bias466-480Polar residues
Compositional bias496-559Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK023903
EMBL· GenBank· DDBJ
BAB14718.1
EMBL· GenBank· DDBJ
mRNA
AC068584
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC109036
EMBL· GenBank· DDBJ
AAI09037.1
EMBL· GenBank· DDBJ
mRNA
BC109037
EMBL· GenBank· DDBJ
AAI09038.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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