Q32KH2 · Q32KH2_CANLF
- ProteinExtracellular sulfatase
- GeneSULF1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids869 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 51 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 87 | Nucleophile | |||
Binding site | 87 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 316 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 317 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExtracellular sulfatase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionQ32KH2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5014104418 | 23-869 | Extracellular sulfatase | ||
Modified residue | 87 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-373 | Sulfatase N-terminal | |||
Compositional bias | 495-510 | Basic and acidic residues | |||
Region | 495-524 | Disordered | |||
Domain | 536-678 | Extracellular sulfatase C-terminal | |||
Coiled coil | 642-669 | ||||
Domain | 681-739 | Extracellular sulfatase C-terminal | |||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length869
- Mass (Da)100,584
- Last updated2005-12-06 v1
- MD5 ChecksumE026C5CD1C0E7F29309990C752B6486F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 495-510 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BN000765 EMBL· GenBank· DDBJ | CAI85011.1 EMBL· GenBank· DDBJ | mRNA |