Q31JC4 · AROE_HYDCU
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids277 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 15-17 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 64 | shikimate (UniProtKB | ChEBI) | |||
Active site | 68 | Proton acceptor | |||
Binding site | 89 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 104 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 129-133 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 153-158 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 217 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 219 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 242 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Piscirickettsiaceae > Hydrogenovibrio
Accessions
- Primary accessionQ31JC4
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000325181 | 1-277 | Shikimate dehydrogenase (NADP+) | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,534
- Last updated2005-12-06 v1
- MD5 Checksum515CED5209C6D7E3B9392CDC1942764C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000109 EMBL· GenBank· DDBJ | ABB40749.1 EMBL· GenBank· DDBJ | Genomic DNA |