Q31JC4 · AROE_HYDCU

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

127720406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site15-17shikimate (UniProtKB | ChEBI)
Binding site64shikimate (UniProtKB | ChEBI)
Active site68Proton acceptor
Binding site89shikimate (UniProtKB | ChEBI)
Binding site104shikimate (UniProtKB | ChEBI)
Binding site129-133NADP+ (UniProtKB | ChEBI)
Binding site153-158NADP+ (UniProtKB | ChEBI)
Binding site217NADP+ (UniProtKB | ChEBI)
Binding site219shikimate (UniProtKB | ChEBI)
Binding site242NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • Ordered locus names
      Tcr_0153

Organism names

Accessions

  • Primary accession
    Q31JC4

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003251811-277Shikimate dehydrogenase (NADP+)

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,534
  • Last updated
    2005-12-06 v1
  • MD5 Checksum
    515CED5209C6D7E3B9392CDC1942764C
MTDLYAVVGNPIAHSKSPLIHRLFAEQTDQDLVYEALLIDTEDTTFQFAISDLIARGYRGINITVPFKLDAFELADELSPRAEVAHAVNTFSFKDGKIFGDNTDGIGLVTDIEENANRPFKDQKVLILGAGGAVQGILQPLLEKQPGLVHIANRTAKRAEVLGKRFETFSPITSSDWEGIPDQAYDIIINGTSASLEGKLPPINSNVVGQDSLVYDMMYGAEPTIFMQWAQQHQPSCQVRDGLGMLVGQAAEAFYIWRGVRPQTQSVIDEVRRLIQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000109
EMBL· GenBank· DDBJ
ABB40749.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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