Q31ID1 · LSPA_HYDCU

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

117220406080100120140160
TypeIDPosition(s)Description
Active site122
Active site140

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • Ordered locus names
      Tcr_0496

Organism names

Accessions

  • Primary accession
    Q31ID1

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane4-24Helical
Transmembrane39-59Helical
Transmembrane69-89Helical
Transmembrane93-113Helical
Transmembrane136-156Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002035971-172Lipoprotein signal peptidase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    172
  • Mass (Da)
    19,129
  • Last updated
    2005-12-06 v1
  • Checksum
    439932AF672A6906
MNKLSSSAITTTWLAMIIIVLDQVTKYWANTSLTMGEPVAILPHLNLTLVYNYGAAFSFLSEVGGWQRWFFTALALVVGTALVIWLAKLPKRWTLEVVAINLVLSGAIGNVIDRILAGRVTDFVDFYIGSWHYATFNVADMGISIGAVLLIISEFWLKPRHEKKAHSTEESV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000109
EMBL· GenBank· DDBJ
ABB41092.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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