Q31DP9 · AROB_HYDCU
- Protein3-dehydroquinate synthase
- GenearoB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids358 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 69-74 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DGEQYK | ||||||
Binding site | 103-107 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GVIGD | ||||||
Binding site | 127-128 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TT | ||||||
Binding site | 140 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 149 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 167-170 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TLNT | ||||||
Binding site | 182 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 245 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 262 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Piscirickettsiaceae > Hydrogenovibrio
Accessions
- Primary accessionQ31DP9
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000231140 | 1-358 | 3-dehydroquinate synthase | |||
Sequence: MKTLTVELGERSYPIFIGQGLLGQAELFKPYVTGTQVLIVSNTTVAPLYLEKAKQAFSGYDVKTVILPDGEQYKNLDVLNQIFDVAIENRFDRKCTFVALGGGVIGDMTGFAAASYQRGVNFIQIPTTLLSQVDSSVGGKTGVNHPKGKNMIGAFHQPECVVIDTDTLNTLEDRELSAGLAEVIKYGLIVDYPFFEWLEQNLPGLLARDPVVLAEAIERSCQNKATIVAKDEKEAGLRALFNLGHTFGHAIEAGMGYGNWLHGEGVSAGMMQAVYLSKLMGDLTQTDQKRIAAILQSAHLPVMPPKEMSVQQFLDLMAGDKKVQAGQIRLVLLKAIGQAYVTGDYPAELLERTLIEYR |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length358
- Mass (Da)39,132
- Last updated2005-12-06 v1
- Checksum2E1E4A2823678C0D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000109 EMBL· GenBank· DDBJ | ABB42724.1 EMBL· GenBank· DDBJ | Genomic DNA |