Q316W7 · SYY_OLEA2
- ProteinTyrosine--tRNA ligase
- GenetyrS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids397 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity
- ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H+ + L-tyrosyl-tRNA(Tyr)
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | RNA binding | |
Molecular Function | tyrosine-tRNA ligase activity | |
Biological Process | tyrosyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Oleidesulfovibrio
Accessions
- Primary accessionQ316W7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000236717 | 1-397 | Tyrosine--tRNA ligase | |||
Sequence: MDMDQQLKTILRGSAEFIDEEELKKKLAKGRPLRVKAGFDPTAPDLHLGHTVLIHKLRHFQELGHTVIFLIGDFTGMIGDPSGRSETRPPLTREQVLQNAETYKKQVFKILDPEKTEVRFNSEWMDKFGAADFIRLASRYTVARMLERDDFEKRYRSNMTISIHEFLYPLVQGYDSVALEADVELGGTDQKFNLLVGRHLQSQEGQEPQCVLTVPILEGLDGVKKMSKSLGNYVGIDEPPADMFGKLMSVSDELMWRYYELITTKTLDEIAELQRRVASGELHPKTAKEELAEHITAQYHGSDKAAEARQGFNAVFAQGCVPDDMPEFSCSCGEDSTPPAFLADSGLAGSRGEAKRLIKQGALSLDGEKLDDPNTPLTAGEYVVRLGKKRFLRLIVR |
Interaction
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 41-50 | 'HIGH' region | ||||
Sequence: PTAPDLHLGH | ||||||
Motif | 225-229 | 'KMSKS' region | ||||
Sequence: KMSKS | ||||||
Domain | 340-396 | S4 RNA-binding | ||||
Sequence: AFLADSGLAGSRGEAKRLIKQGALSLDGEKLDDPNTPLTAGEYVVRLGKKRFLRLIV |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length397
- Mass (Da)44,550
- Last updated2012-03-21 v2
- ChecksumED8C698A033C4115
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000112 EMBL· GenBank· DDBJ | ABB37029.2 EMBL· GenBank· DDBJ | Genomic DNA |