Q2YHE4 · Q2YHE4_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3898 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Acts as a cofactor for the NS3 protease activity.
Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
Plays a role in the regulation of viral RNA replication.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 49 | For N-terminal protease activity | ||||
Sequence: H | ||||||
Active site | 69 | For N-terminal protease activity | ||||
Sequence: C | ||||||
Site | 168-169 | Cleavage; by autolysis | ||||
Sequence: CS | ||||||
Active site | 1658 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1695 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1752 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Pestivirus > Pestivirus suis
Accessions
- Primary accessionQ2YHE4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Virion membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1031-1055 | Helical | ||||
Sequence: FVVLVVVALLGGRYVLWLIVTYIVL | ||||||
Transmembrane | 1076-1095 | Helical | ||||
Sequence: LITHADIEVVVYFLLLYLIM | ||||||
Transmembrane | 1115-1133 | Helical | ||||
Sequence: PVKTMTVALLMISGVAKGG | ||||||
Transmembrane | 1145-1165 | Helical | ||||
Sequence: TSFDIQLMLTVIVVVVMLLAK | ||||||
Transmembrane | 1217-1234 | Helical | ||||
Sequence: WLQYLISTVTGIFLIRVL | ||||||
Transmembrane | 1254-1271 | Helical | ||||
Sequence: FFILVYLISTAIVTRWNL | ||||||
Transmembrane | 1283-1304 | Helical | ||||
Sequence: TLLMVFTMWADILTLILILPTY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-168 | Peptidase C53 | ||||
Sequence: MELNHFELLYKTNKQKPMGAEEPVYDAAGRPFFGDPSEVHPQSTLKLPHDRGRGNIKTTLKNLPRRGDCRSGNHLGPVSGIYVKPGPVFYQDYMGPVYHRAPLEFFHEAQFCEVTKRIGRVTGSDGKLYHIYVCIDGCILLKLAKRGEPRTLKWVRNLTNCPLWVASC | ||||||
Region | 169-242 | Disordered | ||||
Sequence: SDGGASSSKEKKPDRINKGKLKIAPKEHEKDSRTKPPDATIVVEGVKSQVKKKGKVKGKNTQDGLYHNKNKPPE | ||||||
Compositional bias | 175-205 | Basic and acidic residues | ||||
Sequence: SSKEKKPDRINKGKLKIAPKEHEKDSRTKPP | ||||||
Compositional bias | 216-242 | Basic and acidic residues | ||||
Sequence: SQVKKKGKVKGKNTQDGLYHNKNKPPE | ||||||
Domain | 1441-1589 | Peptidase C74 | ||||
Sequence: KELIIKHKVRNEVMVRWFDDEEVYGMPKLIGLVKAATLSKNKNCILCTVCEDRKWGGETCPKCGRFGPPVTCGMTLADFEEKHYKRIFIREDQSEGPVREEHAGYLQYRARGQLFLRNLPVLATKVKMLLVGNLGTEVGDLEHLGWVLR | ||||||
Domain | 1590-1763 | Peptidase S31 | ||||
Sequence: GPAVCKKVTEHERCTTTIMDKLTAFFGVMPRGTTPRAPVRFPTSLLKIRRGLETGWAYTHQGGISSVDHVTCGKDLLVCDSMGRTRVVCQSNNKMTDESEYGVKTDSGCPEGARCYVFNPEAVNISGTKGAMVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGR | ||||||
Domain | 1802-1960 | Helicase ATP-binding | ||||
Sequence: ITTMNRGEFRQITLATGAGKTTELPRSVIEEIGRHKRVLVLIPLRAAAESVYQYMRQKHPSIAFNLRIGEMKEGDMATGITYASYGYFCQMPQPKLRAAMVEYSFIFLDEYHCATPEQLAIMGKIHRFSENLRVVAMTATPAGTVTTTGQKHPIEEFIA | ||||||
Domain | 1978-2179 | Helicase C-terminal | ||||
Sequence: GLKIPVEEMKNNMLVFVPTRNMAVEAAKKLKAKGYNSGYYYSGEDPSNLRVVTSQSPYVVVATNAIESGVTLPDLDVVVDTGLKCEKRIRLSPKMPFIVTGLKRMAVTIGEQAQRRGRVGRVKPGRYYRSQETPVGSKDYHYDLLQAQRYGIEDGINITKSFREMNYDWSLYEEDSLMITQLEILNNLLISEELPMAVKNIM | ||||||
Domain | 3519-3642 | RdRp catalytic | ||||
Sequence: PVAVSFDTKAWDTQVTTRDLEVIKDIQKYYFKKKWHKFIDTLTTHMSEVPVISADGEVYIRKGQRGSGQPDTSAGNSMLNVLTMIYAFCEATGVPYKSFDRVAKIHVCGDDGFLITERALGEKF |
Sequence similarities
Belongs to the pestivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,898
- Mass (Da)437,893
- Last updated2005-12-20 v1
- ChecksumEE9FF0490F87EE97
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 175-205 | Basic and acidic residues | ||||
Sequence: SSKEKKPDRINKGKLKIAPKEHEKDSRTKPP | ||||||
Compositional bias | 216-242 | Basic and acidic residues | ||||
Sequence: SQVKKKGKVKGKNTQDGLYHNKNKPPE |