Q2Y2M0 · SH_AMPV1

Function

function

Viroporin that forms a ion channel probably displaying low ion selectivity. Plays a role in counteracting host innate immunity by inhibiting TLR7/MyD88/TRAF6 signaling and STAT1 phosphorylation, leading to down-regulation of type-I IFN.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell plasma membrane
Cellular Componentmembrane
Cellular Componentvirion membrane
Biological Processproton transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Small hydrophobic protein

Gene names

    • Name
      SH

Organism names

Accessions

  • Primary accession
    Q2Y2M0

Proteomes

Subcellular Location

Virion membrane
; Single-pass type II membrane protein
Host cell membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-28Intravirion
Transmembrane29-49Helical; Signal-anchor for type II membrane protein
Topological domain50-175Virion surface

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00003903741-175Small hydrophobic protein
Glycosylation120N-linked (GlcNAc...) asparagine; by host
Glycosylation138N-linked (GlcNAc...) asparagine; by host
Glycosylation152N-linked (GlcNAc...) asparagine; by host

Post-translational modification

Tyrosine phosphorylated.

Keywords

PTM databases

Interaction

Subunit

Homooligomer (By similarity).
Interacts with glycoprotein G (By similarity).

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region73-108Disordered
Compositional bias74-107Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    175
  • Mass (Da)
    19,544
  • Last updated
    2005-12-20 v1
  • Checksum
    A67FBD5A1C677FCA
MEPLKVSGSGGIPMKTRLNIILEKSINKILIILGLLLIASTVITITLTVEYIRVENELQLCKMGAEVAKTTLEPPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHTNPSCWREEEKCQNITAKWSNCFGTFLPVRVNCTVLRELCDEQLGNHTTVQVSKRCTCIYALNWDCSYA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias74-107Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ009484
EMBL· GenBank· DDBJ
AAY81660.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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