Q2Y2M0 · SH_AMPV1
- ProteinSmall hydrophobic protein
- GeneSH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids175 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Viroporin that forms a ion channel probably displaying low ion selectivity. Plays a role in counteracting host innate immunity by inhibiting TLR7/MyD88/TRAF6 signaling and STAT1 phosphorylation, leading to down-regulation of type-I IFN.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell plasma membrane | |
Cellular Component | membrane | |
Cellular Component | virion membrane | |
Biological Process | proton transmembrane transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSmall hydrophobic protein
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Pneumoviridae > Metapneumovirus > Metapneumovirus avis
- Virus hosts
Accessions
- Primary accessionQ2Y2M0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Single-pass type II membrane protein
Host cell membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-28 | Intravirion | ||||
Sequence: MEPLKVSGSGGIPMKTRLNIILEKSINK | ||||||
Transmembrane | 29-49 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: ILIILGLLLIASTVITITLTV | ||||||
Topological domain | 50-175 | Virion surface | ||||
Sequence: EYIRVENELQLCKMGAEVAKTTLEPPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHTNPSCWREEEKCQNITAKWSNCFGTFLPVRVNCTVLRELCDEQLGNHTTVQVSKRCTCIYALNWDCSYA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000390374 | 1-175 | Small hydrophobic protein | |||
Sequence: MEPLKVSGSGGIPMKTRLNIILEKSINKILIILGLLLIASTVITITLTVEYIRVENELQLCKMGAEVAKTTLEPPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHTNPSCWREEEKCQNITAKWSNCFGTFLPVRVNCTVLRELCDEQLGNHTTVQVSKRCTCIYALNWDCSYA | ||||||
Glycosylation | 120 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 138 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Glycosylation | 152 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N |
Post-translational modification
Tyrosine phosphorylated.
Keywords
- PTM
PTM databases
Interaction
Subunit
Homooligomer (By similarity).
Interacts with glycoprotein G (By similarity).
Interacts with glycoprotein G (By similarity).
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 73-108 | Disordered | ||||
Sequence: EPPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHTN | ||||||
Compositional bias | 74-107 | Polar residues | ||||
Sequence: PPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHT |
Sequence similarities
Belongs to the metapneumovirus small hydrophobic protein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length175
- Mass (Da)19,544
- Last updated2005-12-20 v1
- ChecksumA67FBD5A1C677FCA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 74-107 | Polar residues | ||||
Sequence: PPAQPTKTTPTLTSTRSTTATFKTRPVSRTNHHT |
Keywords
- Technical term