Q2XXQ0 · CRVP_ERYPO
- ProteinCysteine-rich venom protein LIO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids233 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | calcium channel regulator activity | |
Molecular Function | toxin activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameCysteine-rich venom protein LIO1
- Short namesCRVP
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Dipsadidae > Erythrolamprus
Accessions
- Primary accessionQ2XXQ0
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MIVFILLSFAAVLQQSFG | ||||||
Chain | PRO_0000380646 | 19-233 | Cysteine-rich venom protein LIO1 | |||
Sequence: RIDIDSQSTRRPEIQNLIVDTHNSYRRSVSPTATNMLKMEWYPEAAANAERWAYQCVYDHSQKYERVLDGIQCGENIYMYSEFRPWTEVMQSWYDEYRNFIFGVGAHPANALIGHYTQIVWYKSYRVGCAIANCPSYPYNYFYVCQYCPAGNFGGQTATPYNSGTTCADCPSACDNGLCTNPCTSENVFTNCNDMVKESGCQDERMKSICPASCF | ||||||
Disulfide bond | 74↔152 | |||||
Sequence: CVYDHSQKYERVLDGIQCGENIYMYSEFRPWTEVMQSWYDEYRNFIFGVGAHPANALIGHYTQIVWYKSYRVGCAIANC | ||||||
Disulfide bond | 91↔166 | |||||
Sequence: CGENIYMYSEFRPWTEVMQSWYDEYRNFIFGVGAHPANALIGHYTQIVWYKSYRVGCAIANCPSYPYNYFYVCQYC | ||||||
Disulfide bond | 147↔163 | |||||
Sequence: CAIANCPSYPYNYFYVC | ||||||
Disulfide bond | 185↔192 | |||||
Sequence: CADCPSAC | ||||||
Disulfide bond | 188↔197 | |||||
Sequence: CPSACDNGLC | ||||||
Disulfide bond | 210↔228 | |||||
Sequence: CNDMVKESGCQDERMKSIC | ||||||
Disulfide bond | 219↔232 | |||||
Sequence: CQDERMKSICPASC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-165 | SCP | ||||
Sequence: VDTHNSYRRSVSPTATNMLKMEWYPEAAANAERWAYQCVYDHSQKYERVLDGIQCGENIYMYSEFRPWTEVMQSWYDEYRNFIFGVGAHPANALIGHYTQIVWYKSYRVGCAIANCPSYPYNYFYVCQY | ||||||
Domain | 201-233 | ShKT | ||||
Sequence: CTSENVFTNCNDMVKESGCQDERMKSICPASCF |
Sequence similarities
Belongs to the CRISP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length233
- Mass (Da)26,528
- Last updated2005-12-20 v1
- ChecksumB6E9F278123E23DB
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 233 | |||||
Sequence: F |