Q2VG90 · LIP1_MALFU

Function

function

Secreted lipase that releases free fatty acids from monoacylglycerol and triacylglycerol but has no phospholipase or lysophospholipase activities (PubMed:16436442).
Has minor esterase activity (PubMed:16436442).
Due to an absence of fatty acid synthase genes in Malassezia species, secretory lipases are essential for the yeast to generate free fatty acids from degradation of sebum and assimilate them as lipid sources for growth (Probable). Plays important roles not only in lipid metabolism but also in the immune response of host cells and pathogenesis (Probable). Hydrolyzes lipids, such as Tween 20, 40 and 80, with Tween 80 being the best substrate (PubMed:16436442).

Catalytic activity

Activity regulation

Inhibited by different metal ions including Fe2+, Fe3+, Cu2+, and Zn2+ (PubMed:16436442).
The monovalent ions Na+ and K+ exhibit less dramatic inhibition (PubMed:16436442).

pH Dependence

Optimum pH is 5.8.

Temperature Dependence

Optimum temperature is 40 degrees Celsius.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site201Nucleophile
Active site348
Active site382

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functiontriacylglycerol lipase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Gene names

    • Name
      LIP1

Organism names

Accessions

  • Primary accession
    Q2VG90

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000045949227-488Secreted triacylglycerol lipase LIP1
Disulfide bond119↔288
Glycosylation183N-linked (GlcNAc...) asparagine
Glycosylation316N-linked (GlcNAc...) asparagine

Keywords

Expression

Induction

Not expressed in laboratory conditions.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region461-488Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    488
  • Mass (Da)
    54,357
  • Last updated
    2006-01-10 v1
  • Checksum
    2D611BD8B4C97142
MPSMLSLFYLAQSLFLLLLFPLYGHASVLKRGNNDPFYQPPAHWKSKQPGDILRWRKIEPKFIGGDFNVAEAYQLLYRTSQNTPNEPQHTVTTILVPHNAKKDILVVGSVAQDANGQQCTPSAGYTYNSESNFVFWLDETFFLQYLQEGYIMTIPDKEGPKNAFAAGRMEGYMTLDSIRATLNFSKLKLSSNTRIAGYGYSGGAITLGWASSLKPSYAPELNIIGWSFGGTPSNLLGTINHIDGTIFSGLILAGVTGVTDVYPEIHEYIQTVLNSAGREGLEFCRNHCLQEIILRYPLKSIYSYEFQTRGKDVFNNATVQQMFTDLTMGIRPHETPDVPVFMYHAQHDEIVPYDDAHKTAKAWCRNGAQVKFTTYSHYEMGHFTTEITGSVPAFHFIRDLFNGKEVSQGCDFKTEDTLFFNPSVLGGNANEIIDAILGIFGQRIGPEGRILAAKKTVVKGSKSGSSLKSHSHSQTHKHRKDVSTISNA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ155666
EMBL· GenBank· DDBJ
AAZ85120.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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