Q2V9T1 · Q2V9T1_RHDV

Function

function

Displays NTPase activity, but no helicase activity (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NS4, initiates the formation of the replication complex
Probable key protein responsible for the formation of membrane alterations by the virus (By similarity).
Induces the formation of convoluted membranes derived from the host ER (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex (By similarity).
Together with NS2 and NTPase, initiates the formation of the replication complex
Together with NTPase and NS4, initiates the formation of the replication complex (By similarity).
Induces the proliferation of the host smooth ER membranes forming long tubular structures (By similarity).
These remodeled membranes probably form the viral factories that contain the replication complex

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Cellular Componentviral capsid
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncysteine-type endopeptidase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein
  • Alternative names
    • p254

Organism names

Accessions

  • Primary accession
    Q2V9T1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane373-393Helical
Transmembrane405-426Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain492-653SF3 helicase
Domain1109-1244Peptidase C24
Domain1495-1619RdRp catalytic
Region1771-1793Disordered
Compositional bias1777-1791Polar residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,344
  • Mass (Da)
    256,517
  • Last updated
    2006-01-10 v1
  • Checksum
    73B1C68C7D8FC308
MAAMSRLIGMTAAILPEKKPLSFFLDLRDKTPPCCIRATGELAWPVFLGQNENEGPLVTCDKCGKWLDGFGDFGLEDLGNVCLCSIAQQKHKFGPACLCNRAYIHDCGRWRRRSRFLKHYKALNKVIPCAYRFNEGSSPPIFEGEVDDLFVELGAPTSMGFMDKKLLKKGKKLMDKFVDVDEPCLTSRDAGLLDSIASDNTIRAKLEEEYGVEMVQAARDRKDFMKNLRLALDNRPANPVTWYTKLGNITDKGKQWAKKVVYGACKVTEPLKTLASILLVGLHNVIAVDTTVMLSTLKPVNLLAILMDWTNDLTGFVTTLVRLLELYGVVQATVNLIIEGVKSFWDKVICATDRCYDLLKRLFDTFEDSVPTGPTAGCLIFMAFVFSTVVGYLPNNNVITTFMKGAGKLTTFAGVIGAIRTLWITINQHMVAKDLTSIQQKVMTVVKMANEAATLDQLEIVSCLCSDLENTLTNRCTLPSYNQHLGILNASQKVVSDLHTMVLGKINMTKQRPQPVAVIFKGAPGIGKTYLVHRIARDLGCQHPSTINFGLDHFDSYTGEEVAIADEFNTCGDGESWVELFIQMVNTNPCPLNCDKVENKNKVFNSKYLLCTTNSNIILDATHPRAGAFYRRVLIVEARNKAVESWQATRHGAKPGKSCYSKDMSHLAFQVYPHNMPAPGFVFVGDKLVKSQVAPREYKYSELLDLIKSEHPDVASFEGANKFNFIYPDAQYEQALLMWKQYFVMYGCVARLAKSFVDDIPYNQVHISKASDPKIDGCVEYQCKFQHLWRMVPQFVLGCVNMTNQLGTPLTQQQLDRITNGVEGVTVTTVNNILPFHSQTTLINPSFIKLIWAVRKHLKGLSGVTKVAQFIWRVMTNPVDAYGSLVRTLTGAATFSDDPVSTTIICSNCTIQIHSCGGLLVRYSRDPVPVASDNVDRGDQGVDVFTDPNLISGFSWRQIAHLFVEVISHLCANHLVNLATMAALGAVATKAFQGVKGKTKRGRGARVNLGNDEYDEWQAARREFVNAHDMTAEEYLAMKNKAAMGSDDQDSIMFRSWWTRRQLRPDEDQVTIVGRGGVRNEVIRTRARQAPKGPKALDDGGFYDNDYEGLPGFMRHNGSGWMIHIGNGLYISNTHTARSSCSEIVTCSPTTDLCLVKGETIRSVAQIAEGTPVCDWKKSPISTYGIKKTLSDSTKIDVLAYDGCTQTTHGDCGLPLYDSSGKIVAIHTGKLLGFSKMCTLVDLTITKGVYETSNLFCGEPIDYRGITAHRLVGAEPRPPVSGTRYARVPGVPDEYRTGYRPANLGRGDPDSDKSLMNIAVKNLQVYQQEPKLDKVDEFIERAAADVLGYLRFLTKGERQANLNFKAAFNTLDLSTSCGPFVPGKKIDHIKDGVMDQVLAKHLYKCWSVANSGKALHHIYACGLKDELRPLDKVKEGKKRLLWGCDVGVAVCAAAVFHNICHKLKMVARFGPIAVGVDMTSRDVDIIINNLTAKASDFLCLDYSKWDSTMSPCVVRLAIDILADCCEQTELTKSVVLTLKSHPMTILDAMIVQTKRGLPSGMPFTSVINSICHWLLWSAAVYKSCAEIGLHCSNLYEDAPFYTYGDDGVYAMTPMMVSLLPAIIENLRDYGLSPTAADKTEFIDVCPLNKISFLKRTFELTDIGWVSKLDKSSILRQLEWSKTTSRHMVIEETYDLAKEERGVQLEELQVAAAAHGQEFFSFVRKELERQQAYTQFSVYSYDAARKVLADRKRVVSVVPDDEFVNVMEGKARTAPQGEAAGTATTASVPGTTTDGMDPGVVAATSVVTAENSSASVATAGIGGPPQQVDQQETWRTNFYYNDVFTWSVADAPGSILYTVQHSPQNNPFTAVLSQMYAGWAGGMQFRFIVAGSGVFGGRLVAAVIPPGIEIGPGLEVRQFPHVVIDARSLEPVTITMPDLRPNMYHPTGDPGLVPTPVLSVYNNLINPFGGSTNAIQVTVETRPSDDFEFVMIRAPSSKTVDSISPAGLLTTPVLTGVGNDNRWNGQIVGLQPVPGGFSTCNRHWNLNGSTYGWSSPRFADIDHRRGSASYSGNNSTNVLQFWYANAGSAIDNPISQVAPDGFPDMSFVPFNSPNIPTAGWVGFGGIWNSNNGAPAATTVQAYELGFATGAPNNLQPTTNTSGAQTVAKSIYAVVTGTNQNPTGLFVMASGVISTPNASAVTYTPQPDRIVTTPGTPAAAPVGKNTPIMFASVVRRTGDVNAAAGSANGTQYGTGSQPLPVTIGLSLNNYSSALVPGQFFVWQLTFASGFMEIGLSVDGYFYAGTGASTTLIDLTELIDVRPVGPRPSKSTLVFNLGGTTNGLSYV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1777-1791Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ280493
EMBL· GenBank· DDBJ
ABB88924.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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