Q2V6T4 · Q2V6T4_LEIBR
- Proteinmannose-6-phosphate isomerase
- Genempi
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids428 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 106 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 108 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 133 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 273 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 292 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | GDP-mannose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemannose-6-phosphate isomerase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > Leishmania braziliensis species complex
Accessions
- Primary accessionQ2V6T4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-150 | Phosphomannose isomerase type I catalytic | |||
Domain | 187-254 | Phosphomannose isomerase type I helical insertion | |||
Sequence similarities
Belongs to the mannose-6-phosphate isomerase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length428
- Mass (Da)47,177
- Last updated2006-01-10 v1
- Checksum25A4B6CD6199D19D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ288169 EMBL· GenBank· DDBJ | ABB91670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU053117 EMBL· GenBank· DDBJ | ABU25178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU327893 EMBL· GenBank· DDBJ | ABY50483.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU327895 EMBL· GenBank· DDBJ | ABY50485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU327892 EMBL· GenBank· DDBJ | ABY50504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FR799007 EMBL· GenBank· DDBJ | CAM42970.1 EMBL· GenBank· DDBJ | Genomic DNA |