Q2V6T4 · Q2V6T4_LEIBR

  • Protein
    mannose-6-phosphate isomerase
  • Gene
    mpi
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

142850100150200250300350400
Type
IDPosition(s)Description
Binding site106Zn2+ (UniProtKB | ChEBI)
Binding site108Zn2+ (UniProtKB | ChEBI)
Binding site133Zn2+ (UniProtKB | ChEBI)
Binding site273Zn2+ (UniProtKB | ChEBI)
Active site292

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessGDP-mannose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mannose-6-phosphate isomerase
  • EC number

Gene names

    • Name
      mpi
    • Synonyms
      MPI
      , PMI
    • ORF names
      LBRM_32_1750

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MHOM/BR/91/2195
    • MHOM/BR/75/M2904
    • MHOM/PE/93/LEH0022
    • MHOM/PE/93/LEH1642
    • MHOM/PE/94/LEH1829
    • MHOM/PE/88/BAA2072
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > Leishmania braziliensis species complex

Accessions

  • Primary accession
    Q2V6T4

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-150Phosphomannose isomerase type I catalytic
Domain187-254Phosphomannose isomerase type I helical insertion

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    47,177
  • Last updated
    2006-01-10 v1
  • Checksum
    25A4B6CD6199D19D
MSALIKLDASYQDYAWGKNAASSFVAKMKGLTEDQSGKMYAELWVGTHPSCPSKVANGSAQLLEDFLKDPENKKRYFSAAHQSTSFRDTVPYLLKILSIRTALSIQAHPCKKLAEELHAAQPDKYKDPNHKPELICALTPFEALCCFRPLKEIIAYLKRIPQLAALVAADTVLGSYMMAPQSALPAADSDAERQSLKSLMTNLYAAPEDTVTKELRLHLRHIEEKGAQCAEDTLFVRIYKQYPDDVGCWMVYFLNYVQMVPGEALFLSDSEPHAYISGDGVEIMACSDNVVRAGLTPKWKDVPTLVSMLKYSTTGLASARFEKNCSEDAAQWQVQCYQPPAQFPDFCLYRMQYDHTSGSGTTSVTLPTIGLGFCLEGSARVNGTVVCAGDCFAVPYGKVTCQAEERKALVFVASTNDLSGTCPNSLRE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ288169
EMBL· GenBank· DDBJ
ABB91670.1
EMBL· GenBank· DDBJ
Genomic DNA
EU053117
EMBL· GenBank· DDBJ
ABU25178.1
EMBL· GenBank· DDBJ
Genomic DNA
EU327893
EMBL· GenBank· DDBJ
ABY50483.1
EMBL· GenBank· DDBJ
Genomic DNA
EU327895
EMBL· GenBank· DDBJ
ABY50485.1
EMBL· GenBank· DDBJ
Genomic DNA
EU327892
EMBL· GenBank· DDBJ
ABY50504.1
EMBL· GenBank· DDBJ
Genomic DNA
FR799007
EMBL· GenBank· DDBJ
CAM42970.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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