Q2UKD0 · XYL1_ASPOR
- ProteinProbable NAD(P)H-dependent D-xylose reductase xyl1
- Genexyl1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
Catalytic activity
- xylitol + NAD+ = D-xylose + NADH + H+
Pathway
Carbohydrate metabolism; D-xylose degradation.
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 50 | Proton donor | |||
Site | 79 | Lowers pKa of active site Tyr | |||
Binding site | 112 | substrate | |||
Binding site | 166-167 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 215-224 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 271-281 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Molecular Function | D-xylose reductase (NADPH) activity | |
Biological Process | D-xylose catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable NAD(P)H-dependent D-xylose reductase xyl1
- EC number
- Short namesXR
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionQ2UKD0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000393501 | 1-319 | Probable NAD(P)H-dependent D-xylose reductase xyl1 | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)35,868
- Last updated2006-01-24 v1
- Checksum348BB434877572C2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ957890 EMBL· GenBank· DDBJ | ACX46082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ957891 EMBL· GenBank· DDBJ | ACX46083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BA000050 EMBL· GenBank· DDBJ | BAE57985.1 EMBL· GenBank· DDBJ | Genomic DNA |