Q2UBH5 · ATG8_ASPOR

Function

function

Ubiquitin-like modifier involved in autophagosome formation (By similarity).
The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity).
Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity).
Participates also in membrane fusion events that take place in the early secretory pathway (By similarity).
Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Required for both the differentiation of aerial hyphae and conidial germination (PubMed:16896216).

Features

Showing features for site.

1118102030405060708090100110
TypeIDPosition(s)Description
Site116-117Cleavage; by atg4

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautophagosome
Cellular Componentautophagosome membrane
Cellular Componentcytoplasm
Cellular Componentcytoplasmic vesicle
Cellular Componentcytosol
Cellular Componentfungal-type vacuole
Cellular Componentfungal-type vacuole membrane
Cellular Componentlipid droplet
Cellular Componentphagophore assembly site
Molecular Functionphosphatidylethanolamine binding
Biological Processasexual sporulation resulting in formation of a cellular spore
Biological Processautophagy
Biological Processcellular response to nitrogen starvation
Biological Processmacroautophagy
Biological Processprotein secretion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 8
  • Alternative names
    • Autophagy-related ubiquitin-like modifier atg8

Gene names

    • Name
      atg8
    • ORF names
      AO090012000997

Organism names

Accessions

  • Primary accession
    Q2UBH5

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Impairs autophagy as well as the formation of aerial hyphae and conidia.

PTM/Processing

Features

Showing features for chain, lipidation, propeptide.

TypeIDPosition(s)Description
ChainPRO_00003178781-116
Lipidation116Phosphatidylethanolamine amidated glycine
PropeptidePRO_0000317879117-118Removed in mature form

Post-translational modification

The C-terminal 2 residues are removed by atg4 to expose Gly-116 at the C-terminus. The c-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ATG8 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    118
  • Mass (Da)
    13,748
  • Last updated
    2006-01-24 v1
  • Checksum
    8C78807255E14793
MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB246664
EMBL· GenBank· DDBJ
BAE93233.1
EMBL· GenBank· DDBJ
Genomic DNA
BA000052
EMBL· GenBank· DDBJ
BAE61090.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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