Q2U9G3 · LYS4_ASPOR

Function

function

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site392[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site461[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site464[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionhomoaconitate hydratase activity
Molecular Functionmetal ion binding
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoaconitase, mitochondrial
  • EC number
  • Alternative names
    • Homoaconitate hydratase

Gene names

    • Name
      lys4
    • ORF names
      AO090701000041

Organism names

Accessions

  • Primary accession
    Q2U9G3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-29Mitochondrion
ChainPRO_000024791830-775Homoaconitase, mitochondrial

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    775
  • Mass (Da)
    83,730
  • Last updated
    2006-01-24 v1
  • MD5 Checksum
    EAC97DE0F8C4255016741505BF40DC9E
MQSRLMPSGGPGRRWAFLRVPSTPQRRAFASTRFYFQDIFQSQLEDPSSAAVYSSLQASRAVPQTLTEKIVQKYSVGLAKDKFVKSGDYVTISPHRCMTHDNSWPVALKFMSIGATKLHDPKQIVMTLDHDVQNKSEKNLQKYRQIEDFAKHQGVEFYPAGRGIGHQVMVEEGYAWPGTLVVASDSHSNMYGGVGCLGTPIVRTDGASIWATGKTWWQIPPVAKVTLTGVLPPGVTGKDVIVALCGLFDKDDVLNHAIEFTGPEETMRSLSVDARLTIANMTTEWGALSGLFPIDNVLKGWLKGKATTAAMGLAEGPFKTLAPQHFTHPLLEQLFANPLTADKGAKYAKELFLDLSTLSPYVSGPNSVKVATPLKDLEAQNIKVNKAYLVSCTNSRASDIAAAARVFKEAAEKNGGKVPKIADGVEFYVAAASIPEQLAAEEAGDWQALLDAGATPLLPGCAQCIGLGTGLLEAGEVGISASNRNFKGRMGSTDAKAYLGSPEVVAASALTGKLSGPGWYQAPEGLTEVVRGEGDGIREEDRMLTAEQALEKLIGQIDNLVADGEKQFAPEESEESSGDSLTEVYPGFPERVSGEIVFCDADNINTDGIYPGKYTYQDDVSQETMAQVCMSNYDAQFSSIAKEGDILVTGFNFGCGSSREQAATAILAKKIPLVVSGSFGNIFSRNSINNALMGLEVPRLINRLRESFSGEGSDKSLTRRTGWTLTWDVRRSRIEVQEGENGPKWTHQVGELPPNVQEIIAKGGLEKWVKNEIGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000053
EMBL· GenBank· DDBJ
BAE61802.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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