Q2U9G3 · LYS4_ASPOR
- ProteinHomoaconitase, mitochondrial
- Genelys4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids775 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
Catalytic activity
- (2R,3S)-homoisocitrate = cis-homoaconitate + H2O
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 392 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 461 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 464 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | homoaconitate hydratase activity | |
Molecular Function | metal ion binding | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoaconitase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionQ2U9G3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-29 | Mitochondrion | |||
Chain | PRO_0000247918 | 30-775 | Homoaconitase, mitochondrial | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length775
- Mass (Da)83,730
- Last updated2006-01-24 v1
- MD5 ChecksumEAC97DE0F8C4255016741505BF40DC9E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000053 EMBL· GenBank· DDBJ | BAE61802.1 EMBL· GenBank· DDBJ | Genomic DNA |