Q2U639 · ATM_ASPOR
- ProteinSerine/threonine-protein kinase tel1
- Genetel1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids2925 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | DNA repair | |
Biological Process | intracellular signal transduction | |
Biological Process | phosphorylation | |
Biological Process | regulation of metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase tel1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionQ2U639
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000227697 | 1-2925 | Serine/threonine-protein kinase tel1 | ||
Interaction
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 172-211 | Disordered | |||
Compositional bias | 183-204 | Polar residues | |||
Domain | 1844-2467 | FAT | |||
Domain | 2571-2882 | PI3K/PI4K catalytic | |||
Region | 2577-2583 | G-loop | |||
Region | 2749-2757 | Catalytic loop | |||
Region | 2769-2793 | Activation loop | |||
Region | 2853-2879 | Disordered | |||
Domain | 2893-2925 | FATC | |||
Sequence similarities
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,925
- Mass (Da)328,517
- Last updated2006-01-24 v1
- ChecksumECE656F9A991F45E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 183-204 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000053 EMBL· GenBank· DDBJ | BAE62976.1 EMBL· GenBank· DDBJ | Genomic DNA |