Q2U639 · ATM_ASPOR

Function

function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionprotein serine kinase activity
Biological ProcessDNA repair
Biological Processintracellular signal transduction
Biological Processphosphorylation
Biological Processregulation of metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase tel1
  • EC number
  • Alternative names
    • ATM homolog
    • DNA-damage checkpoint kinase tel1
    • Telomere length regulation protein 1

Gene names

    • Name
      tel1
    • ORF names
      AO090120000393

Organism names

Accessions

  • Primary accession
    Q2U639

Proteomes

Subcellular Location

Nucleus
Chromosome, telomere
Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002276971-2925Serine/threonine-protein kinase tel1

Interaction

Subunit

Associates with DNA double-strand breaks.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region172-211Disordered
Compositional bias183-204Polar residues
Domain1844-2467FAT
Domain2571-2882PI3K/PI4K catalytic
Region2577-2583G-loop
Region2749-2757Catalytic loop
Region2769-2793Activation loop
Region2853-2879Disordered
Domain2893-2925FATC

Sequence similarities

Belongs to the PI3/PI4-kinase family. ATM subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,925
  • Mass (Da)
    328,517
  • Last updated
    2006-01-24 v1
  • Checksum
    ECE656F9A991F45E
MAEITLDRTLVLLSSEKQRERSEGLAVSLFVLIVVFVIDPCISSRSSLNDKACHKIFESLFRFISSEKSLYNRGNSKGPSASRLSTCASVLRLAVDALLHNLRAKSVRAVVDHITETLQDTGGSLFELLGVDYTKCLTALLNYPPHVEHLGASEWEKLMGFCLKIMNTQDYEDDRSHTGSDSRSTLDDFLGTGGTPTPSRSMPTLTAREKPKRDKGAISEAVVCIQLLTASVNAPVQEPAAKILHGLVGYVKSSHITGSGHQSAFNSINSVIMRVLSDQSELVQSILLDLIPVICHLWATKLVGLKDELLVTIMLCIVLLTAATRQEPSELLSRYTEDLLGALYKEYIKRPEKDILQVDELVFHQKTSAAVDKILIWPRLESGKSEHNWTVIWAIANLVDLSEEITARSSSPRTSTETLNKRQRLTSMVDEIHRDCASSSGARRVCALQLIPLIPRHHASVDSKSSLLLRLLPNILDENGILASWTMITIASLAGSPNADSPSLRAIWQQAWELTCRASTSQATSRASCILMNSILEYNLLEYSIVAEATSSMLTSVNLNGPSTMSDASLTLWATTTRMTARVNPGSLPNASKQICAWLREVWVIGTVTDRTQLAQLAAFARPLDLLNLLLACTNRHYIPPKPQFRGATSLIAKGWHFLHRSKQLLNYLFQLGGILDFDMWDTDDTIHLETFPRQDPNDNMVLDLLQVKSEMFLQAFQSLYEDKSHHVTVEIVQIVTSFCILVALYTECLPHLSASKFHNLQQNCERLWEIICTFLASHELEFIQGCLVVLSPFLNPEQFSYNPESTISKALLRLVIPLVSLLEAYRRSQRDNLALHNDEPMDLDDTLFNSKDRLAEVTSIVKSNREALPLFQEFSSFQRCITIQLSVLQKTNAFLRNHDQHSSRALVEYLIDLDEVDILAASNSLPYVYRAISGMDRTSLLDILEDLAEKCLQTYELERCEASHLLCIHMMHSFVKAWVSSEADSLSGSASDIYTWFRDVLLAKDMASPSVLVVFSELLVDVINTNASYSSGESNTSPRTSLLKILEKGSIPVKFDVGNLIPRLFGHYSLNDHDAIFNDVLRHLPKESDWVEGIALRLFILGQLASRWHTLLRRSIYHMFETPAHVPHSLQYAEKCICDVANKLGLKDAKELFRLFSSQILYTWTEQESITAMPFSIFSYASIKDMLGDVQDELVGQIIMRAREDEEIEMSKYMGKPFVDLLATSFYKAEAYSIARDISTPPGQGSQPKGVETRLKKILGTEQFMELIDQQFPQTIAAFFGSLDQYEQVERALSKRAKFHDALDGLRCILGKSASKIVLPANQQPSFRARYLIDELEFLCKRSGYELETIWTPTLASYVCRTLLESIHPALGSFHACSVIRKIRVLLCVAGSVMLRDYPFEMTLHAMLPFLVDIYCSEDALGIFWYLLEAGQPYLAETPGLMAGVAVSTLLSLKKFLASPPVDTAQQGQSKIVTANIERFLQWFGEYINTYESSLDAETQESFRRVVKSSQATSTVESHSDDSNERDVILEILDDRSSERSLLSKTVSDHVIALLCADSEEPLGNYHKLNESDRDATANIVAIYQTLQSFNTGSGYRLWAAKVIGRAFATTGKVCDALLREQDLSLFKSQLSDLRLEVHCYSKASILQELCNMLQNNSHLEVGLVERTLQLIISNLARYPDFEQCAGVVPLYLMKAFTWDPYQCPPIPTLAPETERDDAKVNWQTSNSLSQWARGIALFLSKSAAEDPVIGSLSHIIYVIPELAVRILPYMLHDVLLAELKGEANIRQKVSQIFKQALCDVHDTTISHARLAIDCILYLRNQPKPNEATIVERDEWLEIDFAEASLAASRCRLPKTALIFLEIHASRVIFGSRRSSLAKYEAPPDMLHDIFKDIDDPDFFYGIQQSPSLDSVMERLQHESSGFKNLLFQSAQYDSEIQMSADQNAYGVLKALNSTNLQGIANSIFSASGGGFVDTSSSFDSMLQAATNLRQWDIPVSPLNPSPPATVFRAFQSLNTSGSLAEASKSINECLLTTLESLTSASRSAMSLRTAMRVLGVITEVSDVLDARSTEEIDHEWQKIAARDSWLKTTSVHEIGEILNSHEALFSSINRKSYLRSSTNISDHDAQLLEVKAIRQSLHITRTQGIQQASLKSAVYLSKLAHQCSALGINIEGAAKFDLANVLWDQGEMTASIRMLHQLKDQNDLHKQAVPISRAELLVTLVSSLHIDSLRTKPCSFRTNSTSCKGHHVAEARLEKPETIIQDYLLTAVKELKGRSGGEEAGRVYHGFATFCDQQLQNPDGLEDFTRVEQLRNRKEKEVRALEDMMKAAEGREREALKFHRGRTKQWFDLDDREYQRLRRSREAFLQQCLENYLLCLRESETYNNDVLRFCALWLDKSDSDIANAAVSKHLGQVPSRKFAPLMNQLTSRLLDVPDEFQKMLFSLITRICVEHPFHGMYQIFASSKSKGGKDETALSRNRAAGRLVEGLKNDKRIGPTWVAVHNTNINYVRFAIDRPDEKLKSGARVPLRKLQTGGRLEQDAATQKLPPPTMNIEIRVDCDYRDVPKLVKYHPEFTIASGVSAPKIVSAFASNGLRYKQLFKGGNDDLRQDAIMEQVFEQVSNLLKDHQATRQRNLGIRTYKVLPLTSNAGIIEFVPHTIPLHDYLMPAHQKYYPKDMKPNVCRKHISDVQTRSFEQRVRTYRQVTEHFHPVMKYFFMEKFNNPDDWFSKRLSYTRSTAAISILGHVLGLGDRHGHNILLDERTGEVVHIDLGVAFEQGRVLPVPEVVPFRLTRDLVDGMGVTKTEGVFRRCCEFTLETLRRESYSIMTILDVLRYDPLYSWTVSPLRMKKMQDASEAGGGPPMLPGAADQRPSNEPSEADRALTVVAKKLGKTLSVTATVNELIQQATDEKNLAVLYCGWAAYA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias183-204Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000053
EMBL· GenBank· DDBJ
BAE62976.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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