Q2TZ99 · LKHA4_ASPOR

Function

function

Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

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Type
IDPosition(s)Description
Binding site139-141a peptide (UniProtKB | ChEBI)
Binding site271-276a peptide (UniProtKB | ChEBI)
Binding site300Zn2+ (UniProtKB | ChEBI); catalytic
Active site301Proton acceptor
Binding site304Zn2+ (UniProtKB | ChEBI); catalytic
Binding site323Zn2+ (UniProtKB | ChEBI); catalytic
Active site386Proton donor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentfungal-type vacuole lumen
Cellular Componentmultivesicular body
Cellular Componentnucleus
Cellular ComponentNVT complex
Molecular Functionaminopeptidase activity
Molecular Functionepoxide hydrolase activity
Molecular Functionmetallopeptidase activity
Molecular Functionzinc ion binding
Biological Processcellular lipid metabolic process
Biological Processcytoplasm to vacuole targeting by the NVT pathway
Biological Processpeptide catabolic process
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Leucine aminopeptidase 2
  • EC number
  • Alternative names
    • Epoxide hydrolase (EC:3.3.2.10) . EC:3.3.2.10 (UniProtKB | ENZYME | Rhea)
    • Leukotriene A-4 hydrolase homolog (LTA-4 hydrolase)

Gene names

    • ORF names
      AO090011000940

Organism names

Accessions

  • Primary accession
    Q2TZ99

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003249211-615Leucine aminopeptidase 2

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    615
  • Mass (Da)
    69,817
  • Last updated
    2006-01-24 v1
  • Checksum
    B2669E5A98060C85
MATVIHSPRDPNTLSNYNNWVSTHITATFDILFEQKKLVGNVVHKLKSITDARSTEIILDTNHVDIGDVKVDGQASHWELLPPLEPYGAALKINLDQGVGLNEMVEVEISVKTTEKCTALQWLTPAQTSNRKHPYMFSQCQAIHARSIFPCQDTPDVKSTIDFNITSPLPVVASGLPVRGIIEKAQPGSKTLYQFHQKLPIPSYLFALASGDISEAAIGPRSVVATSPDKLSECQWELKADTENFIHAIEKIVYPYAWGEYNVLILPPSFPYGGMENPIFTFATPSIISKDRENVDVIAHELAHSWSGNLVTNASWEHFWLNEGWTTYLERRVSLHGEAYRHFSAIIGWKSLADSVEHFGHDHPFTKLVTDLKGKDPDDAFSSIPYEKGFNFLFHLENLLAKDKFDRFIPHYFTKFKGKSLDSYEFKATMLEFFQHDLEASNLLKNVDWDAWFYAPGLPPKPQFDTSLVDVVYELSSKWKSLPDSSFQPRTSDIEGLTANQIVVLLEQILLFERPLTPELSRVLGEVYSLAKSENIEVSNLYFQVGLRAGDDTVYKPTAELLGKIGRMKFVRPLYRNLQKVNRPLAIETFEKNKDFYHPICRAMVEKDLFGKREE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000055
EMBL· GenBank· DDBJ
BAE65366.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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