Q2TZ99 · LKHA4_ASPOR
- ProteinLeucine aminopeptidase 2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids615 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).
Catalytic activity
- an epoxide + H2O = an ethanediol
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 139-141 | a peptide (UniProtKB | ChEBI) | |||
Binding site | 271-276 | a peptide (UniProtKB | ChEBI) | |||
Binding site | 300 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 301 | Proton acceptor | |||
Binding site | 304 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 323 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 386 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | fungal-type vacuole lumen | |
Cellular Component | multivesicular body | |
Cellular Component | nucleus | |
Cellular Component | NVT complex | |
Molecular Function | aminopeptidase activity | |
Molecular Function | epoxide hydrolase activity | |
Molecular Function | metallopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | cellular lipid metabolic process | |
Biological Process | cytoplasm to vacuole targeting by the NVT pathway | |
Biological Process | peptide catabolic process | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLeucine aminopeptidase 2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionQ2TZ99
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000324921 | 1-615 | Leucine aminopeptidase 2 | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length615
- Mass (Da)69,817
- Last updated2006-01-24 v1
- ChecksumB2669E5A98060C85
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000055 EMBL· GenBank· DDBJ | BAE65366.1 EMBL· GenBank· DDBJ | Genomic DNA |