Q2TK94 · Q2TK94_ADE03
- ProteinHexon protein
- GeneL3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids944 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Miscellaneous
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 769 | Involved in interaction with pre-protein VI | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell nucleus | |
Cellular Component | T=25 icosahedral viral capsid | |
Molecular Function | structural molecule activity | |
Biological Process | microtubule-dependent intracellular transport of viral material towards nucleus | |
Biological Process | symbiont entry into host cell |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHexon protein
- Short namesCP-H
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Human mastadenovirus B
- Virus hosts
Accessions
- Primary accessionQ2TK94
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed; by host | |||
Modified residue | 2 | N-acetylalanine; by host | |||
Chain | PRO_5041494233 | 2-944 | Hexon protein | ||
Modified residue | 932 | Phosphotyrosine; by host | |||
Keywords
- PTM
Expression
Induction
Expressed in the late phase of the viral replicative cycle.
Keywords
- Developmental stage
Interaction
Subunit
Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-627 | Adenovirus Pll hexon N-terminal | |||
Region | 193-216 | Disordered | |||
Region | 229-253 | Disordered | |||
Domain | 628-850 | Adenovirus Pll hexon C-terminal | |||
Sequence similarities
Belongs to the adenoviridae hexon protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length944
- Mass (Da)106,306
- Last updated2006-01-24 v1
- MD5 ChecksumCE75FBC0DB6A004078B0EC2685A07C27
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY854176 EMBL· GenBank· DDBJ | AAX47163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY854178 EMBL· GenBank· DDBJ | AAX47165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF494642 EMBL· GenBank· DDBJ | ABU63115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF494645 EMBL· GenBank· DDBJ | ABU63118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF494650 EMBL· GenBank· DDBJ | ABU63123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456083 EMBL· GenBank· DDBJ | AGP25597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456084 EMBL· GenBank· DDBJ | AGP25598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456085 EMBL· GenBank· DDBJ | AGP25599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456086 EMBL· GenBank· DDBJ | AGP25600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456087 EMBL· GenBank· DDBJ | AGP25601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456088 EMBL· GenBank· DDBJ | AGP25602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456089 EMBL· GenBank· DDBJ | AGP25603.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456090 EMBL· GenBank· DDBJ | AGP25604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456091 EMBL· GenBank· DDBJ | AGP25605.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456092 EMBL· GenBank· DDBJ | AGP25606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456093 EMBL· GenBank· DDBJ | AGP25607.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456094 EMBL· GenBank· DDBJ | AGP25608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456095 EMBL· GenBank· DDBJ | AGP25609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456096 EMBL· GenBank· DDBJ | AGP25610.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456097 EMBL· GenBank· DDBJ | AGP25611.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456098 EMBL· GenBank· DDBJ | AGP25612.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456099 EMBL· GenBank· DDBJ | AGP25613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456100 EMBL· GenBank· DDBJ | AGP25614.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456101 EMBL· GenBank· DDBJ | AGP25615.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456102 EMBL· GenBank· DDBJ | AGP25616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC456103 EMBL· GenBank· DDBJ | AGP25617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM458623 EMBL· GenBank· DDBJ | AKB96230.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM458624 EMBL· GenBank· DDBJ | AKB96231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM458630 EMBL· GenBank· DDBJ | AKB96237.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX384958 EMBL· GenBank· DDBJ | ANQ44538.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748598 EMBL· GenBank· DDBJ | QTW00008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748599 EMBL· GenBank· DDBJ | QTW00009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748600 EMBL· GenBank· DDBJ | QTW00010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748601 EMBL· GenBank· DDBJ | QTW00011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748602 EMBL· GenBank· DDBJ | QTW00012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748603 EMBL· GenBank· DDBJ | QTW00013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748604 EMBL· GenBank· DDBJ | QTW00014.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748605 EMBL· GenBank· DDBJ | QTW00015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748606 EMBL· GenBank· DDBJ | QTW00016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748607 EMBL· GenBank· DDBJ | QTW00017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748608 EMBL· GenBank· DDBJ | QTW00018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748609 EMBL· GenBank· DDBJ | QTW00019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748610 EMBL· GenBank· DDBJ | QTW00020.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748611 EMBL· GenBank· DDBJ | QTW00021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748612 EMBL· GenBank· DDBJ | QTW00022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748613 EMBL· GenBank· DDBJ | QTW00023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748614 EMBL· GenBank· DDBJ | QTW00024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748615 EMBL· GenBank· DDBJ | QTW00025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748616 EMBL· GenBank· DDBJ | QTW00026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748617 EMBL· GenBank· DDBJ | QTW00027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748618 EMBL· GenBank· DDBJ | QTW00028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748641 EMBL· GenBank· DDBJ | QTW00065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748642 EMBL· GenBank· DDBJ | QTW00102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748643 EMBL· GenBank· DDBJ | QTW00139.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748644 EMBL· GenBank· DDBJ | QTW00176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748645 EMBL· GenBank· DDBJ | QTW00213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748646 EMBL· GenBank· DDBJ | QTW00250.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748647 EMBL· GenBank· DDBJ | QTW00287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748648 EMBL· GenBank· DDBJ | QTW00324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748649 EMBL· GenBank· DDBJ | QTW00361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748650 EMBL· GenBank· DDBJ | QTW00398.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748651 EMBL· GenBank· DDBJ | QTW00435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748652 EMBL· GenBank· DDBJ | QTW00472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748653 EMBL· GenBank· DDBJ | QTW00509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748654 EMBL· GenBank· DDBJ | QTW00546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748655 EMBL· GenBank· DDBJ | QTW00583.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748656 EMBL· GenBank· DDBJ | QTW00620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748657 EMBL· GenBank· DDBJ | QTW00657.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748658 EMBL· GenBank· DDBJ | QTW00694.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748659 EMBL· GenBank· DDBJ | QTW00731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748660 EMBL· GenBank· DDBJ | QTW00768.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748661 EMBL· GenBank· DDBJ | QTW00805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748662 EMBL· GenBank· DDBJ | QTW00842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748663 EMBL· GenBank· DDBJ | QTW00879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748664 EMBL· GenBank· DDBJ | QTW00916.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748665 EMBL· GenBank· DDBJ | QTW00953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748666 EMBL· GenBank· DDBJ | QTW00990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748667 EMBL· GenBank· DDBJ | QTW01027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748668 EMBL· GenBank· DDBJ | QTW01064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748669 EMBL· GenBank· DDBJ | QTW01101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748670 EMBL· GenBank· DDBJ | QTW01138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748671 EMBL· GenBank· DDBJ | QTW01175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MW748672 EMBL· GenBank· DDBJ | QTW01212.1 EMBL· GenBank· DDBJ | Genomic DNA |