Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q2TK94 · Q2TK94_ADE03

Function

function

Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

1944100200300400500600700800900
TypeIDPosition(s)Description
Site769Involved in interaction with pre-protein VI

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleus
Cellular ComponentT=25 icosahedral viral capsid
Molecular Functionstructural molecule activity
Biological Processmicrotubule-dependent intracellular transport of viral material towards nucleus
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hexon protein
  • Short names
    CP-H
  • Alternative names
    • Protein II

Gene names

    • Name
      L3

Organism names

Accessions

  • Primary accession
    Q2TK94

Proteomes

Subcellular Location

Host nucleus
Virion
Note: Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed; by host
Modified residue2N-acetylalanine; by host
ChainPRO_50414942332-944Hexon protein
Modified residue932Phosphotyrosine; by host

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain8-627Adenovirus Pll hexon N-terminal
Region193-216Disordered
Region229-253Disordered
Domain628-850Adenovirus Pll hexon C-terminal

Sequence similarities

Belongs to the adenoviridae hexon protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    944
  • Mass (Da)
    106,306
  • Last updated
    2006-01-24 v1
  • MD5 Checksum
    CE75FBC0DB6A004078B0EC2685A07C27
MATPSMMPQWAYMHIAGQDASEYLSPGLVQFARATDTYFSMGNKFRNPTVAPTHDVTTDRSQRLMLRFVPVDREDNTYSYKVRYTLAVGDNRVLDMASTFFDIRGVLDRGPSFKPYSGTAYNSLAPKGAPNTSQWIVTTNRDNAVTTTTNTFGIASMKGDNITKEGLQIGKDITTTEGEEKPIYADKTYQPEPQVGEESWTDTDGTNEKFGGRALKPATNMKPCYGSFARPTNIKGGQAKNRKVKPTTEGGVETEEPDIDMEFFDGRDAVAGALAPEIVLYTENVNLETPDSHVVYKPGTSDNSHANLGQQAMPNRPNYIGFRDNFVGLMYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSLGDRTRYFSMWNQAVDSYDPDVRIIENHGIEDELPNYCFPLDGIGPGHRYQGIKVKTDDANGWEKDANVDTANEIAIGNNLAMEINIQANLWRSFLYSNVALYLPDVYKYTPPNITLPTNTNTYEYMNGRVVSPSLVDSYINIGARWSLDPMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAVKNLLLLPGSYTYEWNFRKDVNMVLQSSLGNDLRTDGATISFTSINLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNIPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFVYSGSIPYLDGTFYLNHTFKKVSIMFDSSVSWPGNDRLLSPNEFEIKRTVDGEGYNVAQCNMTKDWFLVQMLANYNIGYQGFYIPEGYKDRMYSFFRNFQPMSRQVVDEVNYTDYKAVTLPYQHNNSGFVGYLAPTMRQGEPYPANYPYPLIGTTAVKSVTQKKFLCDRTMWRIPFSSNFMSMGALTDLGQNMLYANSAHALDMTFEVDPMDEPTLLYLLFEVFDVVRVHQPHRGVIEAVYLRTPFSAGNATT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY854176
EMBL· GenBank· DDBJ
AAX47163.1
EMBL· GenBank· DDBJ
Genomic DNA
AY854178
EMBL· GenBank· DDBJ
AAX47165.1
EMBL· GenBank· DDBJ
Genomic DNA
EF494642
EMBL· GenBank· DDBJ
ABU63115.1
EMBL· GenBank· DDBJ
Genomic DNA
EF494645
EMBL· GenBank· DDBJ
ABU63118.1
EMBL· GenBank· DDBJ
Genomic DNA
EF494650
EMBL· GenBank· DDBJ
ABU63123.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456083
EMBL· GenBank· DDBJ
AGP25597.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456084
EMBL· GenBank· DDBJ
AGP25598.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456085
EMBL· GenBank· DDBJ
AGP25599.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456086
EMBL· GenBank· DDBJ
AGP25600.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456087
EMBL· GenBank· DDBJ
AGP25601.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456088
EMBL· GenBank· DDBJ
AGP25602.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456089
EMBL· GenBank· DDBJ
AGP25603.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456090
EMBL· GenBank· DDBJ
AGP25604.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456091
EMBL· GenBank· DDBJ
AGP25605.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456092
EMBL· GenBank· DDBJ
AGP25606.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456093
EMBL· GenBank· DDBJ
AGP25607.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456094
EMBL· GenBank· DDBJ
AGP25608.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456095
EMBL· GenBank· DDBJ
AGP25609.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456096
EMBL· GenBank· DDBJ
AGP25610.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456097
EMBL· GenBank· DDBJ
AGP25611.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456098
EMBL· GenBank· DDBJ
AGP25612.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456099
EMBL· GenBank· DDBJ
AGP25613.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456100
EMBL· GenBank· DDBJ
AGP25614.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456101
EMBL· GenBank· DDBJ
AGP25615.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456102
EMBL· GenBank· DDBJ
AGP25616.1
EMBL· GenBank· DDBJ
Genomic DNA
KC456103
EMBL· GenBank· DDBJ
AGP25617.1
EMBL· GenBank· DDBJ
Genomic DNA
KM458623
EMBL· GenBank· DDBJ
AKB96230.1
EMBL· GenBank· DDBJ
Genomic DNA
KM458624
EMBL· GenBank· DDBJ
AKB96231.1
EMBL· GenBank· DDBJ
Genomic DNA
KM458630
EMBL· GenBank· DDBJ
AKB96237.1
EMBL· GenBank· DDBJ
Genomic DNA
KX384958
EMBL· GenBank· DDBJ
ANQ44538.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748598
EMBL· GenBank· DDBJ
QTW00008.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748599
EMBL· GenBank· DDBJ
QTW00009.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748600
EMBL· GenBank· DDBJ
QTW00010.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748601
EMBL· GenBank· DDBJ
QTW00011.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748602
EMBL· GenBank· DDBJ
QTW00012.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748603
EMBL· GenBank· DDBJ
QTW00013.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748604
EMBL· GenBank· DDBJ
QTW00014.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748605
EMBL· GenBank· DDBJ
QTW00015.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748606
EMBL· GenBank· DDBJ
QTW00016.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748607
EMBL· GenBank· DDBJ
QTW00017.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748608
EMBL· GenBank· DDBJ
QTW00018.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748609
EMBL· GenBank· DDBJ
QTW00019.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748610
EMBL· GenBank· DDBJ
QTW00020.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748611
EMBL· GenBank· DDBJ
QTW00021.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748612
EMBL· GenBank· DDBJ
QTW00022.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748613
EMBL· GenBank· DDBJ
QTW00023.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748614
EMBL· GenBank· DDBJ
QTW00024.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748615
EMBL· GenBank· DDBJ
QTW00025.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748616
EMBL· GenBank· DDBJ
QTW00026.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748617
EMBL· GenBank· DDBJ
QTW00027.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748618
EMBL· GenBank· DDBJ
QTW00028.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748641
EMBL· GenBank· DDBJ
QTW00065.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748642
EMBL· GenBank· DDBJ
QTW00102.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748643
EMBL· GenBank· DDBJ
QTW00139.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748644
EMBL· GenBank· DDBJ
QTW00176.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748645
EMBL· GenBank· DDBJ
QTW00213.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748646
EMBL· GenBank· DDBJ
QTW00250.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748647
EMBL· GenBank· DDBJ
QTW00287.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748648
EMBL· GenBank· DDBJ
QTW00324.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748649
EMBL· GenBank· DDBJ
QTW00361.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748650
EMBL· GenBank· DDBJ
QTW00398.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748651
EMBL· GenBank· DDBJ
QTW00435.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748652
EMBL· GenBank· DDBJ
QTW00472.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748653
EMBL· GenBank· DDBJ
QTW00509.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748654
EMBL· GenBank· DDBJ
QTW00546.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748655
EMBL· GenBank· DDBJ
QTW00583.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748656
EMBL· GenBank· DDBJ
QTW00620.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748657
EMBL· GenBank· DDBJ
QTW00657.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748658
EMBL· GenBank· DDBJ
QTW00694.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748659
EMBL· GenBank· DDBJ
QTW00731.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748660
EMBL· GenBank· DDBJ
QTW00768.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748661
EMBL· GenBank· DDBJ
QTW00805.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748662
EMBL· GenBank· DDBJ
QTW00842.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748663
EMBL· GenBank· DDBJ
QTW00879.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748664
EMBL· GenBank· DDBJ
QTW00916.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748665
EMBL· GenBank· DDBJ
QTW00953.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748666
EMBL· GenBank· DDBJ
QTW00990.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748667
EMBL· GenBank· DDBJ
QTW01027.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748668
EMBL· GenBank· DDBJ
QTW01064.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748669
EMBL· GenBank· DDBJ
QTW01101.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748670
EMBL· GenBank· DDBJ
QTW01138.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748671
EMBL· GenBank· DDBJ
QTW01175.1
EMBL· GenBank· DDBJ
Genomic DNA
MW748672
EMBL· GenBank· DDBJ
QTW01212.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help