Q2TAP0 · GOG7B_HUMAN
- ProteinGolgin subfamily A member 7B
- GeneGOLGA7B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids167 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5 (PubMed:31402609).
May be involved in protein transport from Golgi to cell surface
May be involved in protein transport from Golgi to cell surface
Miscellaneous
Shares an exon with the neighboring tail-to-tail oriented gene CRTAC1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Cellular Component | palmitoyltransferase complex | |
Cellular Component | plasma membrane | |
Molecular Function | enzyme binding | |
Biological Process | protein targeting to membrane |
Enzyme and pathway databases
Interacts with ZDHHC5 and it is subsequently S-acylated. Regulates ZDHHC5 localization at the plasma membrane. ZDHHC5/GOLGA7B complex is involved in the regulation of cell adhesion.
Names & Taxonomy
Protein names
- Recommended nameGolgin subfamily A member 7B
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ2TAP0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 179 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000244090 | 1-167 | Golgin subfamily A member 7B | |||
Sequence: MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNGFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKIFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSGSSSGSGSSSGGGGGAGAR | ||||||
Lipidation | 78 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Lipidation | 81 | S-palmitoyl cysteine | ||||
Sequence: C |
Post-translational modification
Palmitoylated by ZDHHC5. Palmitoylation is required for the maintenance of ZDHHC5 at the plasma membrane.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain, but not in lung, nor chondrocytes.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q2TAP0 | HGS O14964 | 3 | EBI-13310443, EBI-740220 | |
BINARY | Q2TAP0 | ZDHHC15 Q96MV8 | 3 | EBI-13310443, EBI-12837904 | |
BINARY | Q2TAP0 | ZDHHC5 Q9C0B5 | 4 | EBI-13310443, EBI-2799626 | |
BINARY | Q2TAP0 | ZNF564 Q8TBZ8 | 3 | EBI-13310443, EBI-10273713 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 140-159 | Polar residues | ||||
Sequence: RCSSGSSSSGSSSGSGSSSG | ||||||
Region | 140-167 | Disordered | ||||
Sequence: RCSSGSSSSGSSSGSGSSSGGGGGAGAR |
Sequence similarities
Belongs to the ERF4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length167
- Mass (Da)18,335
- Last updated2006-06-27 v2
- Checksum1DB5D42080A4A66C
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 83 | in Ref. 2; AAI10811 | ||||
Sequence: T → M | ||||||
Compositional bias | 140-159 | Polar residues | ||||
Sequence: RCSSGSSSSGSSSGSGSSSG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL358938 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC110810 EMBL· GenBank· DDBJ | AAI10811.1 EMBL· GenBank· DDBJ | mRNA |