Q2TAL5 · SMTL2_HUMAN

  • Protein
    Smoothelin-like protein 2
  • Gene
    SMTNL2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentfilamentous actin
Cellular Componentmicrotubule organizing center
Biological Processactin cytoskeleton organization

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Smoothelin-like protein 2

Gene names

    • Name
      SMTNL2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q2TAL5
  • Secondary accessions
    • Q6ZVK6

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_038498162in dbSNP:rs12449695
Natural variantVAR_060164251in dbSNP:rs9916524

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 545 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003172781-461UniProtSmoothelin-like protein 2
Modified residue96UniProtPhosphothreonine
Modified residue101UniProtPhosphoserine
Modified residue (large scale data)101PRIDEPhosphoserine
Modified residue (large scale data)127PRIDEPhosphoserine
Modified residue129UniProtPhosphoserine
Modified residue (large scale data)129PRIDEPhosphoserine
Modified residue134UniProtPhosphoserine
Modified residue (large scale data)134PRIDEPhosphoserine
Modified residue (large scale data)141PRIDEPhosphoserine
Modified residue256UniProtPhosphoserine
Modified residue269UniProtPhosphoserine
Modified residue (large scale data)269PRIDEPhosphoserine
Modified residue274UniProtPhosphothreonine
Modified residue (large scale data)274PRIDEPhosphothreonine
Modified residue278UniProtPhosphoserine
Modified residue (large scale data)278PRIDEPhosphoserine
Modified residue (large scale data)281PRIDEPhosphoserine
Modified residue (large scale data)342PRIDEPhosphoserine
Modified residue344UniProtPhosphoserine
Modified residue (large scale data)344PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for coiled coil, region, compositional bias, domain.

TypeIDPosition(s)Description
Coiled coil55-88
Region87-193Disordered
Compositional bias95-110Pro residues
Region227-248Disordered
Region260-307Disordered
Domain351-458Calponin-homology (CH)

Sequence similarities

Belongs to the smoothelin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q2TAL5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    461
  • Mass (Da)
    50,196
  • Last updated
    2006-01-24 v1
  • Checksum
    A12786420E5796CE
MEPAPDAQEARTVREALGRYEAALEGAVRALHEDMRGLQRGVERRVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSPPPAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDEASESEMRKTSNSCIMENGHQPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQPVTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPSEVITPWTPSPSEKNSSFTWSVPSSGYGAVTASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE

Q2TAL5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
I3L3R4I3L3R4_HUMANSMTNL282

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0309311-144in isoform 2
Compositional bias95-110Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK124452
EMBL· GenBank· DDBJ
BAC85855.1
EMBL· GenBank· DDBJ
mRNA
BC110859
EMBL· GenBank· DDBJ
AAI10860.1
EMBL· GenBank· DDBJ
mRNA
BC105050
EMBL· GenBank· DDBJ
AAI05051.1
EMBL· GenBank· DDBJ
mRNA
BC112177
EMBL· GenBank· DDBJ
AAI12178.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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