Q2RTX4 · Q2RTX4_RHORT

Function

function

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site25-27FMN (UniProtKB | ChEBI)
Binding site78FMN (UniProtKB | ChEBI)
Site105Interacts with tRNA
Active site108Proton donor
Binding site147FMN (UniProtKB | ChEBI)
Binding site179FMN (UniProtKB | ChEBI)
Site191Interacts with tRNA; defines subfamily-specific binding signature
Site194Interacts with tRNA
Binding site219-221FMN (UniProtKB | ChEBI)
Binding site248-249FMN (UniProtKB | ChEBI)
Site314Interacts with tRNA; defines subfamily-specific binding signature
Site317Interacts with tRNA; defines subfamily-specific binding signature

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctiontRNA binding
Molecular FunctiontRNA-dihydrouridine20 synthase activity
Molecular FunctiontRNA-dihydrouridine20a synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine(20/20a) synthase
  • EC number
  • Alternative names
    • U20-specific dihydrouridine synthase
      (U20-specific Dus
      )
    • tRNA-dihydrouridine synthase A

Gene names

    • Name
      dusA
    • Ordered locus names
      Rru_A1621

Organism names

Accessions

  • Primary accession
    Q2RTX4

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-24Disordered
Domain23-324DUS-like FMN-binding

Sequence similarities

Belongs to the Dus family. DusA subfamily.
Belongs to the dus family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    349
  • Mass (Da)
    37,800
  • Last updated
    2006-01-24 v1
  • Checksum
    8697330561D649F3
MMVSAPAPRSQPDRSQPDRRLSVAPMMDWTDRHDRWFLRQITKRTLLYTEMITAQALLHADPGRFLDHHPDEHPLALQLGGSDPRALAEATRLAAPFGFAEINLNVGCPSDRVSSGRFGACLMADPALVAECLSAMAEASNAPVTIKHRIGIDDLDSYDQLVGFVDQVARSGIATIIVHARKAWLKGLSPKENREIPPLRHDVVHRLKADFPGLEVILNGGITTLTQALDHLGSGDPAAPAVDGVMIGRAAYETPYMLAQADGLIFGEATPAPSRHEVALALLPYLDAMTARGEPVKRLTRHILGLFHGQPGARAYRRHLGEAGVRPDATAQVLIDALAHIPALDEAES

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000230
EMBL· GenBank· DDBJ
ABC22421.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp