Q2RAD9 · H32_ORYSJ

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Caution

To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me = methylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me = methylated Lys-10; H3S10ph = phosphorylated Ser-11; H3T11ph = phosphorylated Thr-12; H3K14ac = acetylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me = methylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me = methylated Lys-24; H3K27me = methylated Lys-28; H3S28ph = phosphorylated Ser-29; H3K36me = methylated Lys-37.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H3.2

Gene names

    • ORF names
      OsJ_004096
      , P0505D12.33
    • Ordered locus names
      Os01g0866200
      , LOC_Os01g64640
    • ORF names
      OsJ_014206
      , OSJNBb0108J11.17
    • Ordered locus names
      Os04g0419600
      , LOC_Os04g34240
    • ORF names
      OSJNBb0042J17.11
    • Ordered locus names
      Os05g0438700
      , LOC_Os05g36280
    • Name
      H3R-11
    • ORF names
      OsJ_019386
      , P0702F05.33
    • Ordered locus names
      Os06g0159501
      , LOC_Os06g06460
    • ORF names
      P0681F10.3
      , P0702F05.38
    • Ordered locus names
      Os06g0160001

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q2RAD9
  • Secondary accessions
    • P05203
    • P05329
    • P05330
    • P08860
    • P69247

Proteomes

    • Identifier
    • Component
      Chromosome 1, Chromosome 11, Chromosome 4, Chromosome 5, Chromosome 6
    • Identifier
    • Component
      Chromosome 1, Chromosome 4, Chromosome 6
    • Identifier
    • Component
      Chromosome 1, Chromosome 11, Chromosome 4, Chromosome 5, Chromosome 6

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
ChainPRO_00002212892-136UniProtHistone H3.2
Modified residue5UniProtN6-methylated lysine
Modified residue10UniProtN6-acetyllysine; alternate
Modified residue10UniProtN6-methylated lysine; alternate
Modified residue11UniProtPhosphoserine
Modified residue12UniProtPhosphothreonine
Modified residue15UniProtN6-acetyllysine
Modified residue19UniProtN6-acetyllysine; alternate
Modified residue19UniProtN6-methylated lysine; alternate
Modified residue24UniProtN6-acetyllysine; alternate
Modified residue24UniProtN6-methylated lysine; alternate
Modified residue28UniProtN6-methylated lysine
Modified residue29UniProtPhosphoserine
Modified residue37UniProtN6-methylated lysine
Modified residue (large scale data)81PTMeXchangePhosphothreonine

Post-translational modification

Acetylation is generally linked to gene activation. Can be acetylated to form H3K9ac, H3K14ac, H3K18ac and H3K23ac. H3K9ac could compete with H3K9me and prevent gene silencing. H3K9ac is restricted to euchromatin (By similarity).
Methylated to form mainly H3K4me, H3K9me, H3K18me, H3K23me, H3K27me and H3K36me. H3K4me1/2/3, H3K9me3, H3K27me3 and H3K36me1/2/3 are typical marks for euchromatin, whereas heterochromatic chromocenters are enriched in H3K9me1/2 and H3K27me1/2. H2BK143ub1 is probably prerequisite for H3K4me (By similarity).
Can be phosphorylated to form H3S10ph, H3T11ph and H3S28ph.

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-43Disordered

Sequence similarities

Belongs to the histone H3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    136
  • Mass (Da)
    15,268
  • Last updated
    2006-07-11 v1
  • Checksum
    F1FB03A849777A61
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0P0WA64A0A0P0WA64_ORYSJOs04g0419600274
A0A0P0VAU1A0A0P0VAU1_ORYSJOs01g0866200167
A0A0P0WMX5A0A0P0WMX5_ORYSJOs05g0438700200
A0A0P0WSK4A0A0P0WSK4_ORYSJOs06g0160100224

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict87in Ref. 1; AAA33907
Sequence conflict91in Ref. 1; AAA33907
Sequence conflict99in Ref. 1; AAA33907

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M15664
EMBL· GenBank· DDBJ
AAA33907.1
EMBL· GenBank· DDBJ
Genomic DNA
X13678
EMBL· GenBank· DDBJ
CAA31969.1
EMBL· GenBank· DDBJ
Genomic DNA
X13680
EMBL· GenBank· DDBJ
CAA31970.1
EMBL· GenBank· DDBJ
Genomic DNA
AP003270
EMBL· GenBank· DDBJ
BAC01212.1
EMBL· GenBank· DDBJ
Genomic DNA
AL606618
EMBL· GenBank· DDBJ
CAE02924.1
EMBL· GenBank· DDBJ
Genomic DNA
AC134930
EMBL· GenBank· DDBJ
AAT07615.1
EMBL· GenBank· DDBJ
Genomic DNA
AB026295
EMBL· GenBank· DDBJ
BAA81840.1
EMBL· GenBank· DDBJ
Genomic DNA
AB026295
EMBL· GenBank· DDBJ
BAA81841.1
EMBL· GenBank· DDBJ
Genomic DNA
AP005828
EMBL· GenBank· DDBJ
BAD46448.1
EMBL· GenBank· DDBJ
Genomic DNA
AP005828
EMBL· GenBank· DDBJ
BAD46453.1
EMBL· GenBank· DDBJ
Genomic DNA
AP005828
EMBL· GenBank· DDBJ
BAD46454.1
EMBL· GenBank· DDBJ
Genomic DNA
AC112209
EMBL· GenBank· DDBJ
AAX92719.1
EMBL· GenBank· DDBJ
Genomic DNA
DP000010
EMBL· GenBank· DDBJ
ABA91537.2
EMBL· GenBank· DDBJ
Genomic DNA
AP008207
EMBL· GenBank· DDBJ
BAF06818.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008210
EMBL· GenBank· DDBJ
BAF14690.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008211
EMBL· GenBank· DDBJ
BAF17574.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008212
EMBL· GenBank· DDBJ
BAF18791.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008217
EMBL· GenBank· DDBJ
BAF27636.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014957
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP014960
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP014961
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP014962
EMBL· GenBank· DDBJ
BAS96275.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014967
EMBL· GenBank· DDBJ
BAT12754.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000138
EMBL· GenBank· DDBJ
EAZ14271.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000141
EMBL· GenBank· DDBJ
EAZ30723.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000143
EMBL· GenBank· DDBJ
EAZ35903.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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