Q2RAD9 · H32_ORYSJ
- ProteinHistone H3.2
- GeneH3R-11; H3R-21
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids136 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | structural constituent of chromatin |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameHistone H3.2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ2RAD9
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Chain | PRO_0000221289 | 2-136 | UniProt | Histone H3.2 | |||
Sequence: ARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA | |||||||
Modified residue | 5 | UniProt | N6-methylated lysine | ||||
Sequence: K | |||||||
Modified residue | 10 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 10 | UniProt | N6-methylated lysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 11 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 12 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 15 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 19 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 19 | UniProt | N6-methylated lysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 24 | UniProt | N6-acetyllysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 24 | UniProt | N6-methylated lysine; alternate | ||||
Sequence: K | |||||||
Modified residue | 28 | UniProt | N6-methylated lysine | ||||
Sequence: K | |||||||
Modified residue | 29 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 37 | UniProt | N6-methylated lysine | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 81 | PTMeXchange | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Acetylation is generally linked to gene activation. Can be acetylated to form H3K9ac, H3K14ac, H3K18ac and H3K23ac. H3K9ac could compete with H3K9me and prevent gene silencing. H3K9ac is restricted to euchromatin (By similarity).
Methylated to form mainly H3K4me, H3K9me, H3K18me, H3K23me, H3K27me and H3K36me. H3K4me1/2/3, H3K9me3, H3K27me3 and H3K36me1/2/3 are typical marks for euchromatin, whereas heterochromatic chromocenters are enriched in H3K9me1/2 and H3K27me1/2. H2BK143ub1 is probably prerequisite for H3K4me (By similarity).
Can be phosphorylated to form H3S10ph, H3T11ph and H3S28ph.
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFR |
Sequence similarities
Belongs to the histone H3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length136
- Mass (Da)15,268
- Last updated2006-07-11 v1
- ChecksumF1FB03A849777A61
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0P0WA64 | A0A0P0WA64_ORYSJ | Os04g0419600 | 274 | ||
A0A0P0VAU1 | A0A0P0VAU1_ORYSJ | Os01g0866200 | 167 | ||
A0A0P0WMX5 | A0A0P0WMX5_ORYSJ | Os05g0438700 | 200 | ||
A0A0P0WSK4 | A0A0P0WSK4_ORYSJ | Os06g0160100 | 224 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 87 | in Ref. 1; AAA33907 | ||||
Sequence: S → T | ||||||
Sequence conflict | 91 | in Ref. 1; AAA33907 | ||||
Sequence: A → R | ||||||
Sequence conflict | 99 | in Ref. 1; AAA33907 | ||||
Sequence: A → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M15664 EMBL· GenBank· DDBJ | AAA33907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X13678 EMBL· GenBank· DDBJ | CAA31969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X13680 EMBL· GenBank· DDBJ | CAA31970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP003270 EMBL· GenBank· DDBJ | BAC01212.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL606618 EMBL· GenBank· DDBJ | CAE02924.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC134930 EMBL· GenBank· DDBJ | AAT07615.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB026295 EMBL· GenBank· DDBJ | BAA81840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB026295 EMBL· GenBank· DDBJ | BAA81841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP005828 EMBL· GenBank· DDBJ | BAD46448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP005828 EMBL· GenBank· DDBJ | BAD46453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP005828 EMBL· GenBank· DDBJ | BAD46454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC112209 EMBL· GenBank· DDBJ | AAX92719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DP000010 EMBL· GenBank· DDBJ | ABA91537.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008207 EMBL· GenBank· DDBJ | BAF06818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008210 EMBL· GenBank· DDBJ | BAF14690.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008211 EMBL· GenBank· DDBJ | BAF17574.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008212 EMBL· GenBank· DDBJ | BAF18791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008217 EMBL· GenBank· DDBJ | BAF27636.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014957 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AP014960 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AP014961 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AP014962 EMBL· GenBank· DDBJ | BAS96275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014967 EMBL· GenBank· DDBJ | BAT12754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000138 EMBL· GenBank· DDBJ | EAZ14271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000141 EMBL· GenBank· DDBJ | EAZ30723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000143 EMBL· GenBank· DDBJ | EAZ35903.1 EMBL· GenBank· DDBJ | Genomic DNA |