Q2QL91 · CAV2_MICMU

Function

function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1 (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcaveola
Cellular Componentcytoplasmic vesicle
Cellular Componentfocal adhesion
Cellular ComponentGolgi membrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane raft
Cellular Componentsarcolemma
Molecular FunctionD1 dopamine receptor binding
Molecular Functionmolecular adaptor activity
Molecular Functionprotein kinase binding
Biological Processcaveola assembly
Biological Processendoplasmic reticulum organization
Biological Processinsulin receptor signaling pathway
Biological Processmitochondrion organization
Biological Processnegative regulation of endothelial cell proliferation
Biological Processpositive regulation of dopamine receptor signaling pathway
Biological Processpositive regulation of MAPK cascade
Biological Processregulation of cytosolic calcium ion concentration
Biological Processskeletal muscle fiber development
Biological Processvesicle docking
Biological Processvesicle fusion

Names & Taxonomy

Protein names

  • Recommended name
    Caveolin-2

Gene names

    • Name
      CAV2

Organism names

Accessions

  • Primary accession
    Q2QL91

Proteomes

Subcellular Location

Golgi apparatus membrane
; Peripheral membrane protein
Cell membrane
; Peripheral membrane protein
Membrane, caveola
; Peripheral membrane protein
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).

Features

Showing features for topological domain, intramembrane.

Type
IDPosition(s)Description
Topological domain1-86Cytoplasmic
Intramembrane87-107Helical
Topological domain108-162Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002263411-162Caveolin-2
Modified residue19Phosphotyrosine
Modified residue20Phosphoserine
Modified residue36Phosphoserine

Keywords

Interaction

Subunit

Homodimer. Caveolin-1 and -2 colocalize and form a stable hetero-oligomeric complex (By similarity).

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    162
  • Mass (Da)
    18,233
  • Last updated
    2006-01-24 v1
  • MD5 Checksum
    A9E23289F6F228CE66DE799E425319FF
MGLETEKADVQLFLDDDSYSHHGDVDFADPEKFADSDHDRDPHRLNSHLKVGFEDVIAEPMTTHSCDKVWICSHALFEISKYVMYKFLTVFLAIPLAFVAGILFATLSCLHIWIIMPFVKTCLMVLPSVQTIWKSVTDVIIAPLCTSVGRSFSSISLQLSHD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C5VSL8A0A8C5VSL8_MICMUCAV2112

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DP000022
EMBL· GenBank· DDBJ
ABB89818.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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