Q2QL91 · CAV2_MICMU
- ProteinCaveolin-2
- GeneCAV2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids162 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1 (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | focal adhesion | |
Cellular Component | Golgi membrane | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane raft | |
Cellular Component | sarcolemma | |
Molecular Function | D1 dopamine receptor binding | |
Molecular Function | molecular adaptor activity | |
Molecular Function | protein kinase binding | |
Biological Process | caveola assembly | |
Biological Process | endoplasmic reticulum organization | |
Biological Process | insulin receptor signaling pathway | |
Biological Process | mitochondrion organization | |
Biological Process | negative regulation of endothelial cell proliferation | |
Biological Process | positive regulation of dopamine receptor signaling pathway | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | regulation of cytosolic calcium ion concentration | |
Biological Process | skeletal muscle fiber development | |
Biological Process | vesicle docking | |
Biological Process | vesicle fusion |
Names & Taxonomy
Protein names
- Recommended nameCaveolin-2
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Cheirogaleidae > Microcebus
Accessions
- Primary accessionQ2QL91
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Cell membrane ; Peripheral membrane protein
Membrane, caveola ; Peripheral membrane protein
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).
Features
Showing features for topological domain, intramembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-86 | Cytoplasmic | |||
Intramembrane | 87-107 | Helical | |||
Topological domain | 108-162 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000226341 | 1-162 | Caveolin-2 | ||
Modified residue | 19 | Phosphotyrosine | |||
Modified residue | 20 | Phosphoserine | |||
Modified residue | 36 | Phosphoserine | |||
Keywords
- PTM
Interaction
Subunit
Homodimer. Caveolin-1 and -2 colocalize and form a stable hetero-oligomeric complex (By similarity).
Structure
Sequence
- Sequence statusComplete
- Length162
- Mass (Da)18,233
- Last updated2006-01-24 v1
- MD5 ChecksumA9E23289F6F228CE66DE799E425319FF
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C5VSL8 | A0A8C5VSL8_MICMU | CAV2 | 112 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DP000022 EMBL· GenBank· DDBJ | ABB89818.1 EMBL· GenBank· DDBJ | Genomic DNA |