The histone demethylase Kdm3 prevents auto-immune piRNAs production in <i>Drosophila</i>.Casier K., Autaa J., Gueguen N., Delmarre V., Marie P.P., Ronsseray S., Carre C., Brasset E., Teysset L., Boivin A.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCSci Adv 9:eade3872-eade3872 (2023)Mapped to24
Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster.Mongelli V., Lequime S., Kousathanas A., Gausson V., Blanc H., Nigg J., Quintana-Murci L., Elena S.F., Saleh M.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCNat Ecol Evol 6:565-578 (2022)Mapped to99+
Coleopteran-specific StaufenC functions like <i>Drosophila melanogaster</i> Loquacious-PD in dsRNA processing.Kim K., Koo J., Yoon J.S., Reddy Palli S.View abstractCategoriesSequences, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCRNA Biol 18:467-477 (2021)Mapped to22
Single-molecule analysis of processive double-stranded RNA cleavage by Drosophila Dicer-2.Naganuma M., Tadakuma H., Tomari Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCNat. Commun. 12:4268-4268 (2021)Cited in1Mapped to14
In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster.Donelick H.M., Talide L., Bellet M., Aruscavage P.J., Lauret E., Aguiar E.R.G.R., Marques J.T., Meignin C., Bass B.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCRNA 26:1847-1861 (2020)Cited in1Mapped to36
Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila.Deng P., Khan A., Jacobson D., Sambrani N., McGurk L., Li X., Jayasree A., Hejatko J., Shohat-Ophir G.[...], Keegan L.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCNat Commun 11:1580-1580 (2020)Mapped to66
NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models.Singh M.D., Jensen M., Lasser M., Huber E., Yusuff T., Pizzo L., Lifschutz B., Desai I., Kubina A.[...], Girirajan S.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCPLoS Genet 16:e1008590-e1008590 (2020)Mapped to99+
<i>Drosophila</i> PSI controls circadian period and the phase of circadian behavior under temperature cycle via <i>tim</i> splicing.Foley L.E., Ling J., Joshi R., Evantal N., Kadener S., Emery P.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCElife 8:e50063-e50063 (2019)Mapped to99+
Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.Zhang S.X., Rogulja D., Crickmore M.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCCurr Biol 29:3216-3228.e9 (2019)Mapped to40
The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.Hill A.S., Jain P., Folan N.E., Ben-Shahar Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCPLoS Genet 15:e1008288-e1008288 (2019)Mapped to61
Non-self mutation: double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases.van Eyk C.L., Samaraweera S.E., Scott A., Webber D.L., Harvey D.P., Mecinger O., O'Keefe L.V., Cropley J.E., Young P.[...], Richards R.I.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCHum Mol Genet 28:3000-3012 (2019)Mapped to46
Robust CRISPR/Cas9-Mediated Tissue-Specific Mutagenesis Reveals Gene Redundancy and Perdurance in <i>Drosophila</i>.Poe A.R., Wang B., Sapar M.L., Ji H., Li K., Onabajo T., Fazliyeva R., Gibbs M., Qiu Y.[...], Han C.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCGenetics 211:459-472 (2019)Mapped to28
Topoisomerase 3beta interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila.Lee S.K., Xue Y., Shen W., Zhang Y., Joo Y., Ahmad M., Chinen M., Ding Y., Ku W.L.[...], Wang W.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCNat Commun 9:4946-4946 (2018)Mapped to48
The somatic piRNA pathway controls germline transposition over generations.Barckmann B., El-Barouk M., Pelisson A., Mugat B., Li B., Franckhauser C., Fiston Lavier A.S., Mirouze M., Fablet M., Chambeyron S.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCNucleic Acids Res 46:9524-9536 (2018)Mapped to12
Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in <i>Drosophila</i>.Harsh S., Ozakman Y., Kitchen S.M., Paquin-Proulx D., Nixon D.F., Eleftherianos I.View abstractAnnotationmutating Dicer-2 results in enhanced Zika virus load and increased susceptibility to Zika virus infectionCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246, GeneRif: 36993PubMedEurope PMCJ Immunol 201:3058-3072 (2018)Mapped to59
<i>Drosophila</i> HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development.Yanku Y., Bitman-Lotan E., Zohar Y., Kurant E., Zilke N., Eilers M., Orian A.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCCells 7:E151-E151 (2018)Mapped to47
Dual-layer transposon repression in heads of <i>Drosophila melanogaster</i>.van den Beek M., da Silva B., Pouch J., Ali Chaouche M.E.A., Carre C., Antoniewski C.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCRNA 24:1749-1760 (2018)Mapped to14
Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in <i>Drosophila melanogaster</i>.Widmer Y.F., Bilican A., Bruggmann R., Sprecher S.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCGenetics 209:1167-1181 (2018)Mapped to83
Loquacious-PD removes phosphate inhibition of Dicer-2 processing of hairpin RNAs into siRNAs.Fukunaga R.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCBiochem. Biophys. Res. Commun. 498:1022-1027 (2018)Cited in2Mapped to13
Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.Genenncher B., Durdevic Z., Hanna K., Zinkl D., Mobin M.B., Senturk N., Da Silva B., Legrand C., Carre C.[...], Schaefer M.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCCell Rep 22:1861-1874 (2018)Mapped to29
RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates.Palmer W.H., Hadfield J.D., Obbard D.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCGenetics 208:1585-1599 (2018)Mapped to99+
Pleiotropic and novel phenotypes in the Drosophila gut caused by mutation of drop-dead.Conway S., Sansone C.L., Benske A., Kentala K., Billen J., Vanden Broeck J., Blumenthal E.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCJ Insect Physiol 105:76-84 (2018)Mapped to12
Missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila.Deciphering Developmental Disorders StudyStraub J., Konrad E.D.H., Gruener J., Toutain A., Bok L.A., Cho M.T., Crawford H.P., Dubbs H., Douglas G.[...], Zweier C.View abstractCategoriesSequences, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCAm. J. Hum. Genet. 102:44-57 (2018)Cited in2Mapped to15
Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections.Chow J., Marka Z., Bartos I., Marka S., Kagan J.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCCell Host Microbe 22:48-60.e5 (2017)Mapped to14
Reversible perturbations of gene regulation after genome editing in Drosophila cells.Kunzelmann S., Forstemann K.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0034246PubMedEurope PMCPLoS One 12:e0180135-e0180135 (2017)Mapped to16