Natural selection drives extremely rapid evolution in antiviral RNAi genes.Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J.View abstractCited forNUCLEOTIDE SEQUENCEStrainG196CategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCCurr. Biol. 16:580-585 (2006)Cited in172Mapped to12
Key arginine residues in R2D2 dsRBD1 and dsRBD2 lead the siRNA recognition in Drosophila melanogaster RNAi pathway.Aute R., Waghela N., Deshmukh M.V.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCBiophys Chem 310:107247-107247 (2024)Mapped to7
Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.Deng T., Su S., Yuan X., He J., Huang Y., Ma J., Wang J.View abstractAnnotationStructural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.SourceFlyBase: FBgn0031951, GeneRif: 34066PubMedEurope PMCNat Commun 14:5228-5228 (2023)Cited in1Mapped to21
Chemical shift assignments of dsRBD1 and linker region of R2D2, a siRNA binding protein in the Drosophila RNAi pathway.Aute R., Deshmukh M.V.View abstractAnnotationChemical shift assignments of dsRBD1 and linker region of R2D2 a siRNA binding protein in the Drosophila RNAi pathway.CategoriesFunctionSourceFlyBase: FBgn0031951, GeneRif: 34066PubMedEurope PMCBiomol NMR Assign 17:211-215 (2023)Mapped to17
Drosophila as a Model for Human Viral Neuroinfections.Benoit I., Di Curzio D., Civetta A., Douville R.N.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCCells 11:2685-2685 (2022)Mapped to99+
Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured <i>Drosophila</i> cells.Gao Y., Zhu Y., Sun Q., Chen D.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCSTAR Protoc 3:101596-101596 (2022)Mapped to22
Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.Yamaguchi S., Naganuma M., Nishizawa T., Kusakizako T., Tomari Y., Nishimasu H., Nureki O.View abstractAnnotationStructure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.CategoriesFamily & Domains, StructureSourceFlyBase: FBgn0031951, GeneRif: 34066PubMedEurope PMCNature 607:393-398 (2022)Cited in11Mapped to17
Sensing microbial infections in the Drosophila melanogaster genetic model organism.Liegeois S., Ferrandon D.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCImmunogenetics 74:35-62 (2022)Mapped to99+
Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators.Pennemann F.L., Mussabekova A., Urban C., Stukalov A., Andersen L.L., Grass V., Lavacca T.M., Holze C., Oubraham L.[...], Pichlmair A.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCNat Commun 12:7009-7009 (2021)Mapped to99+
Coleopteran-specific StaufenC functions like <i>Drosophila melanogaster</i> Loquacious-PD in dsRNA processing.Kim K., Koo J., Yoon J.S., Reddy Palli S.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0031951PubMedEurope PMCRNA Biol 18:467-477 (2021)Mapped to22
A Glimpse of "Dicer Biology" Through the Structural and Functional Perspective.Paturi S., Deshmukh M.V.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCFront Mol Biosci 8:643657-643657 (2021)Mapped to35
Genetic determinants of antiviral immunity in dipteran insects - Compiling the experimental evidence.Rosendo Machado S., van der Most T., Miesen P.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCDev Comp Immunol 119:104010-104010 (2021)Mapped to99+
Sensing and signalling viral infection in drosophila.Schneider J., Imler J.L.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCDev Comp Immunol 117:103985-103985 (2021)Mapped to99+
In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster.Donelick H.M., Talide L., Bellet M., Aruscavage P.J., Lauret E., Aguiar E.R.G.R., Marques J.T., Meignin C., Bass B.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0031951PubMedEurope PMCRNA 26:1847-1861 (2020)Cited in1Mapped to36
Roles for Drosophila cap1 2'-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2.Lee S., Hong J.S., Lim D.H., Lee Y.S.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0031951PubMedEurope PMCInsect Biochem. Mol. Biol. 123:103415-103415 (2020)Cited in2Mapped to24
Small regulatory noncoding RNAs in Drosophila melanogaster: biogenesis and biological functions.Soleimani S., Valizadeh Arshad Z., Moradi S., Ahmadi A., Davarpanah S.J., Azimzadeh Jamalkandi S.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCBrief Funct Genomics 19:309-323 (2020)Mapped to86
Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila.Nitschko V., Kunzelmann S., Frohlich T., Arnold G.J., Forstemann K.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCNucleic Acids Res 48:3906-3921 (2020)Mapped to60
Drosophila immunity against natural and nonnatural viral pathogens.Tafesh-Edwards G., Eleftherianos I.View abstractSourceFlyBase: FBgn0031951PubMedEurope PMCVirology 540:165-171 (2020)Mapped to65
Non-self mutation: double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases.van Eyk C.L., Samaraweera S.E., Scott A., Webber D.L., Harvey D.P., Mecinger O., O'Keefe L.V., Cropley J.E., Young P.[...], Richards R.I.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0031951PubMedEurope PMCHum Mol Genet 28:3000-3012 (2019)Mapped to46
Generating and working with Drosophila cell cultures: Current challenges and opportunities.Luhur A., Klueg K.M., Zelhof A.C.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCWiley Interdiscip Rev Dev Biol 8:e339-e339 (2019)Mapped to99+
Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems.Tsuboyama K., Tadakuma H., Tomari Y.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0031951PubMedEurope PMCMol Cell 70:722-729.e4 (2018)Mapped to30
RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates.Palmer W.H., Hadfield J.D., Obbard D.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0031951PubMedEurope PMCGenetics 208:1585-1599 (2018)Mapped to99+
Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.Coll O., Guitart T., Villalba A., Papin C., Simonelig M., Gebauer F.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0031951PubMedEurope PMCRNA 24:529-539 (2018)Cited in4Mapped to28
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs- PD/Dcr-2 complex in RNA interference.Tants J.-N., Fesser S., Kern T., Stehle R., Geerlof A., Wunderlich C., Juen M., Hartlmuller C., Boettcher R.[...], Sattler M.View abstractCategoriesFunctionSourceFlyBase: FBgn0031951PubMedEurope PMCNucleic Acids Res. 45:12536-12550 (2017)Cited in2Mapped to22
Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies.Sinha N.K., Bass B.L.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0031951PubMedEurope PMCMethods 126:54-65 (2017)Mapped to22