Q2PE51 · BNP_CRODO

Function

function

Bradykinin-potentiating peptide both inhibits the activity of the angiotensin-converting enzyme (ACE) and enhances the action of bradykinin by inhibiting the peptidases that inactivate it. It acts as an indirect hypotensive agent (By similarity).

Bradykinin inhibitor peptide homolog

antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (By similarity).
Has no demonstrable hypotensive activity when injected intravenously in rats

C-type natriuretic peptide

has a vasorelaxant activity in rat aortic strips and a diuretic potency in anesthetized rats (By similarity).
May act by activating natriuretic receptors (NPR1 and/or NPR2)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionhormone activity
Molecular Functionpeptidase inhibitor activity
Molecular Functiontoxin activity
Biological Processregulation of blood pressure
Biological Processvasodilation

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    Q2PE51
  • Secondary accessions
    • Q2PE50

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant31in isoform 2
Natural variant36in isoform 2

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, modified residue, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-23
PropeptidePRO_000033589824-30
Modified residue31Pyrrolidone carboxylic acid
PeptidePRO_000033589931-40Bradykinin-potentiating peptide-1
PropeptidePRO_000033590041-43
Modified residue44Pyrrolidone carboxylic acid
PeptidePRO_000033590144-49Bradykinin-potentiating peptide-2
PropeptidePRO_000033590250-78
PeptidePRO_000033590379-89Bradykinin inhibitor peptide homolog
PropeptidePRO_000033590490-157
PeptidePRO_0000335905160-181C-type natriuretic peptide
Disulfide bond165↔181

Keywords

Expression

Tissue specificity

Venom gland.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region74-153Disordered
Compositional bias103-117Polar residues

Sequence similarities

In the N-terminal section; belongs to the bradykinin-potentiating peptide family.
In the C-terminal section; belongs to the natriuretic peptide family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    181
  • Mass (Da)
    18,514
  • Last updated
    2006-02-07 v1
  • Checksum
    CF5ADC5B93747C15
MFVSRLAASGLLLLALLAVSLDGKPLQQWSQRWPHLEIPPLVVQNWKSPTQLQARESPAGGTTALREELSLGPEAALDTPPAGPDGGPRGSKAAAAAPQRLSKSKGASATSAASRDLRTDGKQARQNWGRLVSPDHHSAAGGGGGGGGGARRLKGLAKKRAGNGCFGLKLDRIGSMSGLGC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias103-117Polar residues

Mass Spectrometry

Bradykinin inhibitor peptide homolog

Molecular mass is 1,020.5 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB246364
EMBL· GenBank· DDBJ
BAE73272.1
EMBL· GenBank· DDBJ
mRNA
AB246365
EMBL· GenBank· DDBJ
BAE73273.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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