Q2MV57 · TECT2_MOUSE

  • Protein
    Tectonic-2
  • Gene
    Tctn2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentciliary transition zone
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentmembrane
Cellular ComponentMKS complex
Biological Processcilium assembly
Biological Processprotein localization to ciliary transition zone
Biological Processsmoothened signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tectonic-2

Gene names

    • Name
      Tctn2
    • Synonyms
      Tect2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q2MV57
  • Secondary accessions
    • Q6PDZ5
    • Q8C0B3
    • Q9CXF5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein
Note: Localizes at the transition zone, a region between the basal body and the ciliary axoneme.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain26-665Extracellular
Transmembrane666-682Helical
Topological domain683-700Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice have ventricular septal defects and can display right-sided stomach. The embryos exhibit microphthalmia, cleft palate and polydactyly. Embryos lack also nodal cilia. Cilia in neural tubes are scarce and morphologically defective, and failed to elongate axonemes. Basal bodies dock to the plasma membrane in Tctn2 null neural epithelium. No Arl13b ciliary staining in defective Tctn2 embryos perineural mesenchyme suggesting that, as in Tctn1 null mutants, defective Tctn2 cilia lack Arl13b. Tctn1 and Tctn2 share a common function, with both affecting ciliogenesis in a tissue-specific manner.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_000022979926-700Tectonic-2
Glycosylation76N-linked (GlcNAc...) asparagine
Glycosylation82N-linked (GlcNAc...) asparagine
Glycosylation146N-linked (GlcNAc...) asparagine
Glycosylation156N-linked (GlcNAc...) asparagine
Glycosylation389N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Significant expression is observed in brain, kidney and eye.

Developmental stage

At 8.5 dpc, expressed in the neural tube, most notably in the rhombomere of the future hindbrain. By 10.5 dpc, expressed throughout the brain, the length of the neural tube, the growing edge of the limb buds, heart, and eyes. Strong expression is observed in the kidney at 14.5 dpc.

Interaction

Subunit

Part of the tectonic-like complex (also named B9 complex).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the tectonic family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q2MV57-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    700
  • Mass (Da)
    77,111
  • Last updated
    2006-04-04 v2
  • Checksum
    59B1C3A973EFD581
MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRATLVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGLDWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVIPNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHHCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADASYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLENMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSISGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAGMNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDLLTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRILTAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMPHPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILLRHPWVRMCKARDSAAIYH

Q2MV57-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0177661-121in isoform 2
Sequence conflict42in Ref. 1; ABB90561
Sequence conflict57in Ref. 1; ABB90561
Sequence conflict79in Ref. 1; ABB90561
Sequence conflict272in Ref. 2; BAC27569

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ278869
EMBL· GenBank· DDBJ
ABB90561.1
EMBL· GenBank· DDBJ
mRNA
AK014476
EMBL· GenBank· DDBJ
BAB29379.1
EMBL· GenBank· DDBJ
mRNA
AK031829
EMBL· GenBank· DDBJ
BAC27569.1
EMBL· GenBank· DDBJ
mRNA
BC058375
EMBL· GenBank· DDBJ
AAH58375.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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