Q2MFP3 · DOIAD_STREY

Function

function

Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD+ or NADP+, forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4.
Antibiotic biosynthesis; paromomycin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site59Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site88Zn2+ 2 (UniProtKB | ChEBI)
Binding site91Zn2+ 2 (UniProtKB | ChEBI)
Binding site94Zn2+ 2 (UniProtKB | ChEBI)
Binding site102Zn2+ 2 (UniProtKB | ChEBI)
Binding site143Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Functionoxidoreductase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-deoxy-scyllo-inosamine dehydrogenase
  • EC number
  • Short names
    DOIA dehydrogenase

Gene names

    • Name
      parE

Organism names

Accessions

  • Primary accession
    Q2MFP3

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002340471-3392-deoxy-scyllo-inosamine dehydrogenase

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    35,458
  • Last updated
    2006-02-21 v1
  • Checksum
    76E63F9530E1859D
MKALMFKAPLQAVLTERDVPEPAPGEALVKLAYNSICGSDLSFYKGVWHGFTYPVVPGHEWSGTVVEAGGGAADLVGQNVVGDLTVACGSCRHCTVGKPTLCADLQELGFTRDGACAEYMTVPTGNLHRLPEGLSLREATQVEPLAVALNAVDRLAVTAGEKVAITGAGGIGLLLAQAVRLRGAEVTVLAEPVTERRQAAHALGVPHTVGGDPGELVGFVEKHPELTPDVVLEASGYPLAVQEAVEAVRSGGRIGLIGYRIEEAATMAPHHIVVKVLSLQASMGPGDRFGEAIELLAAGAVDVDALLSHEFGLADHDRALDVALRRADGNTRSYFNLRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ628955
EMBL· GenBank· DDBJ
CAF32372.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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