Q2MFP2 · GLDSA_STREY
- ProteinL-glutamine:2-deoxy-scyllo-inosose aminotransferase
- GeneparS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids424 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (2-DOI) to form 2-deoxy-scyllo-inosamine (2-DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (keto-2-DOIA) into 2-deoxystreptamine (2-DOS).
Catalytic activity
- 2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
Cofactor
Pathway
Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4.
Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 4/4.
Antibiotic biosynthesis; paromomycin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | transaminase activity | |
Biological Process | antibiotic biosynthetic process | |
Biological Process | polysaccharide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-glutamine:2-deoxy-scyllo-inosose aminotransferase
- EC number
- Short namesL-glutamine:DOI aminotransferase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionQ2MFP2
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000233022 | 1-424 | L-glutamine:2-deoxy-scyllo-inosose aminotransferase | ||
Modified residue | 202 | N6-(pyridoxal phosphate)lysine | |||
Structure
Family & Domains
Sequence similarities
Belongs to the DegT/DnrJ/EryC1 family. L-glutamine:2-deoxy-scyllo-inosose/scyllo-inosose aminotransferase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length424
- Mass (Da)45,105
- Last updated2006-02-21 v1
- Checksum6D7C86696A5496DF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ628955 EMBL· GenBank· DDBJ | CAF32373.1 EMBL· GenBank· DDBJ | Genomic DNA |