Q2M3M2 · SC5A9_HUMAN

  • Protein
    Sodium/glucose cotransporter 4
  • Gene
    SLC5A9
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Electrogenic Na+-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular exosome
Cellular Componentplasma membrane
Molecular Functionglucose:sodium symporter activity
Molecular Functionlow-affinity glucose:sodium symporter activity
Biological Processhexose transmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/glucose cotransporter 4
  • Short names
    Na(+)/glucose cotransporter 4; hSGLT4
  • Alternative names
    • Solute carrier family 5 member 9

Gene names

    • Name
      SLC5A9
    • Synonyms
      SGLT4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q2M3M2
  • Secondary accessions
    • B3KY87
    • B7ZL45
    • B7ZL47
    • E9PAK4
    • E9PJ08
    • Q5TET3

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-36Extracellular
Transmembrane37-57Helical
Topological domain58-75Cytoplasmic
Transmembrane76-98Helical
Topological domain99-114Extracellular
Transmembrane115-135Helical
Topological domain136-157Cytoplasmic
Transmembrane158-178Helical
Topological domain179-190Extracellular
Transmembrane191-211Helical
Topological domain212-217Cytoplasmic
Transmembrane218-238Helical
Topological domain239-275Extracellular
Transmembrane276-296Helical
Topological domain297-317Cytoplasmic
Transmembrane318-338Helical
Topological domain339-383Extracellular
Transmembrane384-406Helical
Topological domain407-427Cytoplasmic
Transmembrane428-448Helical
Topological domain449-459Extracellular
Transmembrane460-480Helical
Topological domain481-487Cytoplasmic
Transmembrane488-508Helical
Topological domain509-530Extracellular
Transmembrane531-551Helical
Topological domain552-660Cytoplasmic
Transmembrane661-681Helical

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_068963124in dbSNP:rs141515954
Natural variantVAR_043166152in dbSNP:rs212989
Natural variantVAR_043167207in dbSNP:rs12047252
Natural variantVAR_043168269in dbSNP:rs212991

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 886 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003338051-681Sodium/glucose cotransporter 4
Glycosylation251N-linked (GlcNAc...) asparagine
Modified residue604Phosphoserine
Modified residue605Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the small intestine, kidney and liver.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region579-614Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q2M3M2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    681
  • Mass (Da)
    74,073
  • Last updated
    2008-05-20 v2
  • Checksum
    618D27DC590EE826
MSKELAAMGPGASGDGVRTETAPHIALDSRVGLHAYDISVVVIYFVFVIAVGIWSSIRASRGTIGGYFLAGRSMSWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNATWLLLALGWVFVPVYIAAGVVTMPQYLKKRFGGQRIQVYMSVLSLILYIFTKISTDIFSGALFIQMALGWNLYLSTGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHESTPEISERPAGECPAGGGAAENSSLGQEQPEAPSRSWGKLLWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNINAVLLLAINIFLWGYFA

Q2M3M2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 113-113: N → NMRKSRSGGDRGIHPRSHGRTGVRSQ

Q2M3M2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 113-113: N → NMRKSRSGGDRGIHPRSHGRTG

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WD86F8WD86_HUMANSLC5A9283
H0YC92H0YC92_HUMANSLC5A976
H0Y5P9H0Y5P9_HUMANSLC5A9173

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_044577113in isoform 2
Alternative sequenceVSP_057168113in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK131200
EMBL· GenBank· DDBJ
BAG54749.1
EMBL· GenBank· DDBJ
mRNA
AL109659
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471059
EMBL· GenBank· DDBJ
EAX06857.1
EMBL· GenBank· DDBJ
Genomic DNA
BC104857
EMBL· GenBank· DDBJ
AAI04858.1
EMBL· GenBank· DDBJ
mRNA
BC104863
EMBL· GenBank· DDBJ
AAI04864.1
EMBL· GenBank· DDBJ
mRNA
BC143570
EMBL· GenBank· DDBJ
AAI43571.1
EMBL· GenBank· DDBJ
mRNA
BC143572
EMBL· GenBank· DDBJ
AAI43573.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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