Q2LWX9 · THIM_SYNAS
- ProteinHydroxyethylthiazole kinase
- GenethiM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids270 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Catalytic activity
- 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H+
Cofactor
Pathway
Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | substrate | |||
Binding site | 123 | ATP (UniProtKB | ChEBI) | |||
Binding site | 170 | ATP (UniProtKB | ChEBI) | |||
Binding site | 197 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | hydroxyethylthiazole kinase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | phosphorylation | |
Biological Process | thiamine biosynthetic process | |
Biological Process | thiamine diphosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxyethylthiazole kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Syntrophia > Syntrophales > Syntrophaceae > Syntrophus
Accessions
- Primary accessionQ2LWX9
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000336574 | 1-270 | Hydroxyethylthiazole kinase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)28,368
- Last updated2006-02-21 v1
- MD5 Checksum7ED47361A9BE1DBC7FEBEBD655B7BB96
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000252 EMBL· GenBank· DDBJ | ABC78586.1 EMBL· GenBank· DDBJ | Genomic DNA |