Q2LVL5 · LPXD_SYNAS
- ProteinUDP-3-O-acylglucosamine N-acyltransferase
- GenelpxD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids363 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Catalytic activity
- a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a (3R)-hydroxyacyl-[ACP] = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + holo-[ACP] + H+
Pathway
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 239 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | N-acyltransferase activity | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-3-O-acylglucosamine N-acyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Syntrophia > Syntrophales > Syntrophaceae > Syntrophus
Accessions
- Primary accessionQ2LVL5
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000264449 | 1-363 | UDP-3-O-acylglucosamine N-acyltransferase | ||
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 342-363 | Disordered | |||
Sequence similarities
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length363
- Mass (Da)38,941
- Last updated2006-02-21 v1
- ChecksumA70BEB6CFDD81FF2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000252 EMBL· GenBank· DDBJ | ABC78127.1 EMBL· GenBank· DDBJ | Genomic DNA |