Q2LMP1 · WNT3A_CHICK
- ProteinProtein Wnt-3a
- GeneWNT3A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:17488271).
Regulates chick apical ectodermal ridge formation (PubMed:17488271).
Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity).
Regulates chick apical ectodermal ridge formation (PubMed:17488271).
Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein Wnt-3a
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ2LMP1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Isoform 2
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_0000392924 | 19-352 | Protein Wnt-3a | ||
Disulfide bond | 77↔88 | ||||
Glycosylation | 87 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 92 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 128↔136 | ||||
Disulfide bond | 138↔155 | ||||
Disulfide bond | 203↔217 | ||||
Disulfide bond | 205↔212 | ||||
Lipidation | 209 | O-palmitoleoyl serine; by PORCN | |||
Disulfide bond | 281↔312 | ||||
Disulfide bond | 297↔307 | ||||
Glycosylation | 298 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 311↔351 | ||||
Disulfide bond | 327↔342 | ||||
Disulfide bond | 329↔339 | ||||
Disulfide bond | 334↔335 | ||||
Post-translational modification
Palmitoleoylation is required for efficient binding to frizzled receptors (PubMed:22046319).
Depalmitoleoylation leads to inhibit the Wnt signaling pathway (By similarity).
Depalmitoleoylation leads to inhibit the Wnt signaling pathway (By similarity).
Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding (By similarity).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in cornea. Isoform 1 is expressed in the primitive streak, dorsal neural tube, proximal otic vesicle, the apical ectodermal ridge and the epithelium of feather buds.
Developmental stage
In the eye, the expression was observed at stage 23 in the ocular surface epithelium ventral to the corneal epithelium. Strongly expressed in the entire ocular surface at stage 26 including the corneal epithelium. Remained strongly expressed at stage 30.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q2LMP1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length352
- Mass (Da)39,629
- Last updated2006-02-21 v1
- ChecksumEE558AC4B2225B3A
Q2LMP1-2
- Name2
- NoteNot secreted.
- Differences from canonical
- 1-24: MASFGYFLFLCGLSQALSSYPIWW → MKSFCSEVVAKSRLGLKQWGWCGWTPMGSAWKKWISEQRSSLELWDVG
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V1A0A9 | A0A8V1A0A9_CHICK | WNT3A | 356 | ||
A0A8V1A7U9 | A0A8V1A7U9_CHICK | WNT3A | 333 | ||
A0A8V1A7V3 | A0A8V1A7V3_CHICK | WNT3A | 376 | ||
A0A8V1ACU2 | A0A8V1ACU2_CHICK | WNT3A | 334 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_038851 | 1-24 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB024080 EMBL· GenBank· DDBJ | BAA83743.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ022307 EMBL· GenBank· DDBJ | AAY87456.1 EMBL· GenBank· DDBJ | mRNA | ||
EF068232 EMBL· GenBank· DDBJ | ABK90821.1 EMBL· GenBank· DDBJ | mRNA |