Q2LC84 · NUMB_RAT

  • Protein
    Protein numb homolog
  • Gene
    Numb
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulates clathrin-mediated receptor endocytosis (By similarity).
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentbasolateral plasma membrane
Cellular Componentclathrin-coated pit
Cellular Componentclathrin-coated vesicle
Cellular Componentcytoplasm
Cellular Componentcytoplasmic vesicle
Cellular Componentdendritic spine
Cellular Componentearly endosome
Cellular Componentendosome membrane
Cellular Componentglutamatergic synapse
Cellular Componentpostsynaptic density
Molecular Functionalpha-catenin binding
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Biological Processadherens junction organization
Biological Processaxonogenesis
Biological Processcell differentiation
Biological Processforebrain development
Biological Processlateral ventricle development
Biological Processlung epithelial cell differentiation
Biological Processnegative regulation of Notch signaling pathway
Biological Processnegative regulation of protein localization to plasma membrane
Biological Processnervous system development
Biological Processneuroblast division in subventricular zone
Biological Processneuroblast proliferation
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of dendrite morphogenesis
Biological Processpositive regulation of neurogenesis
Biological Processpositive regulation of polarized epithelial cell differentiation
Biological Processregulation of neuron differentiation
Biological Processregulation of postsynapse assembly
Biological Processregulation of postsynaptic neurotransmitter receptor internalization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein numb homolog

Gene names

    • Name
      Numb

Organism names

  • Taxonomic identifier
  • Strain
    • Lewis
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q2LC84
  • Secondary accessions
    • B2GVA9
    • F1MAI8

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Endosome membrane
; Peripheral membrane protein
Note: Localizes to perinuclear endosomes in an AAK1-dependent manner.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis275Loss of phosphorylation by CaMK1.
Mutagenesis294Loss of phosphorylation by CaMK1.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004129011-652Protein numb homolog
Modified residue102Phosphothreonine
Modified residue194Phosphoserine
Modified residue242Phosphothreonine
Modified residue243Phosphoserine
Modified residue275Phosphoserine; by CaMK1
Modified residue294Phosphoserine; by CaMK1
Modified residue426Phosphoserine
Modified residue437Phosphothreonine
Modified residue439Phosphoserine
Modified residue635Phosphoserine

Post-translational modification

Phosphorylated on Ser-275 and Ser-294 by CaMK1.
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with SIAH1 (By similarity).
Interacts with LNX (By similarity).
Interacts with CDH1 (By similarity).
Interacts with TFAP2A and TFAP2B (PubMed:17022975).
Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis (By similarity).
Interacts with AAK1 (By similarity).
May interact with DUOXA1 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain37-173PID
Region213-256Disordered
Region418-440Disordered
Region543-580Disordered
Compositional bias547-580Polar residues
Region624-652Disordered
Compositional bias626-644Polar residues

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q2LC84-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    i/i
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    652
  • Mass (Da)
    70,596
  • Last updated
    2011-09-21 v2
  • Checksum
    B4AD582D3A0CA45A
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQLQDAKKAETDKTVGPSVAPGNSAPSPSSPTSPTLDPTASLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNTVPEVEGEAESISSLCSQITSAFSTPCEDPFSSAPMTKPVTLVAPQSPVLQANGTDSALHVLTAKPASTALAPVAMPVRETNPWAHAPDAANKEIAAIHSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPAAIAPPAPPFQGHAFLTSQPVPVGVVPPLQPAFVSTQSYPVANGMPYPASNVPVVGITPSQMVANVFGTAGHPQATHPHQSPSLAKQQTFPQYETSSATTSPFFKPSAQHLNGSAAFNGVDNSGLVSGNRPAQVPPGTCPVDPFEAQWAALESKPKQRTNPSPTNPFSSDAQKAFEIEL

Q2LC84-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q2LC85Q2LC85_RATNumb641
Q2LC87Q2LC87_RATNumb603
H9KVE4H9KVE4_RATNumb540

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04181168-78in isoform 2
Sequence conflict459in Ref. 1; ABC69737
Compositional bias547-580Polar residues
Compositional bias626-644Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC166596
EMBL· GenBank· DDBJ
AAI66596.1
EMBL· GenBank· DDBJ
mRNA
DQ336705
EMBL· GenBank· DDBJ
ABC69737.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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