Q2KN97 · CYTSA_CHICK
- ProteinCytospin-A
- GeneSPECC1L
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1118 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | filamentous actin | |
Cellular Component | gap junction | |
Cellular Component | microtubule organizing center | |
Cellular Component | spindle | |
Biological Process | actin cytoskeleton organization | |
Biological Process | cell division |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCytospin-A
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ2KN97
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with beta-tubulin, acetylated alpha-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000231022 | 1-1118 | Cytospin-A | |||
Sequence: MKKASRSVGSVPKVPGVNKTQTTEKTKPESGSSLSAVTKLSKPGTSASLLKTKSNDDLLAGMASGGGVTMTNGVKAKKSTCASTVSSTTGTTMSTLENKPRTVAGSTARRSTSSGTKESSSSRERIRDRSRLSQSKKLPLAGQGSNDTVLAKRSRSRTNPESDIRMSKSKSDNQISDKAALEAKVNDLLTLAKTKDVEILHLRNELRDMRAQLGLNEDQVEGDEKSEEKEAIVVHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITAGNHSDGGGTLTSSVEGSAPGSMEDLLSQDEHTLMDNQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGVPSIERSRKGSSGNASEVSVACLTERIHQMEENQHSTAEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDEDMKSGRYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERNHHMERIIESEQKSKTAIASTLEEYKATVASDQIEMNRLKAQLEHEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEELAHTRNDANRLQDAIAKVEDEYRVFQEEAKKQIEDLNVTLEKLRAELDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKNLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVPSPAAATIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISASKPLATLTDKRPSYAEIPVQEHLLRTSSTSRPASLPRVPAMESAKSISVSRRSSEEIKRDISAPDGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAAESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
May interact with both microtubules and actin cytoskeleton.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-176 | Disordered | ||||
Sequence: MKKASRSVGSVPKVPGVNKTQTTEKTKPESGSSLSAVTKLSKPGTSASLLKTKSNDDLLAGMASGGGVTMTNGVKAKKSTCASTVSSTTGTTMSTLENKPRTVAGSTARRSTSSGTKESSSSRERIRDRSRLSQSKKLPLAGQGSNDTVLAKRSRSRTNPESDIRMSKSKSDNQIS | ||||||
Compositional bias | 14-53 | Polar residues | ||||
Sequence: VPGVNKTQTTEKTKPESGSSLSAVTKLSKPGTSASLLKTK | ||||||
Compositional bias | 73-119 | Polar residues | ||||
Sequence: GVKAKKSTCASTVSSTTGTTMSTLENKPRTVAGSTARRSTSSGTKES | ||||||
Compositional bias | 120-134 | Basic and acidic residues | ||||
Sequence: SSSRERIRDRSRLSQ | ||||||
Compositional bias | 136-153 | Polar residues | ||||
Sequence: KKLPLAGQGSNDTVLAKR | ||||||
Compositional bias | 154-176 | Basic and acidic residues | ||||
Sequence: SRSRTNPESDIRMSKSKSDNQIS | ||||||
Coiled coil | 193-281 | |||||
Sequence: KTKDVEILHLRNELRDMRAQLGLNEDQVEGDEKSEEKEAIVVHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALGFSLEQ | ||||||
Compositional bias | 299-319 | Polar residues | ||||
Sequence: ITAGNHSDGGGTLTSSVEGSA | ||||||
Region | 299-324 | Disordered | ||||
Sequence: ITAGNHSDGGGTLTSSVEGSAPGSME | ||||||
Region | 359-391 | Disordered | ||||
Sequence: SSDDALDAPSSSESEGVPSIERSRKGSSGNASE | ||||||
Coiled coil | 396-450 | |||||
Sequence: CLTERIHQMEENQHSTAEELQATLQELADLQQITQELNSENERLGEEKVILMESL | ||||||
Coiled coil | 488-808 | |||||
Sequence: RYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERNHHMERIIESEQKSKTAIASTLEEYKATVASDQIEMNRLKAQLEHEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEELAHTRNDANRLQDAIAKVEDEYRVFQEEAKKQIEDLNVTLEKLRAELDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIKNLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKSRKQEEERGRV | ||||||
Region | 856-879 | Disordered | ||||
Sequence: PSPAAATIPRTPLSPSPMKTPPAA | ||||||
Compositional bias | 863-877 | Pro residues | ||||
Sequence: IPRTPLSPSPMKTPP | ||||||
Region | 921-1002 | Disordered | ||||
Sequence: TSSTSRPASLPRVPAMESAKSISVSRRSSEEIKRDISAPDGASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDP | ||||||
Compositional bias | 967-991 | Polar residues | ||||
Sequence: LMAMGTTSPQLSLSSSPTASVTPTT | ||||||
Domain | 1012-1117 | Calponin-homology (CH) | ||||
Sequence: GSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELNSQDKRRNFTLAFQAAESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFE |
Sequence similarities
Belongs to the cytospin-A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,118
- Mass (Da)124,909
- Last updated2006-04-04 v2
- Checksum8BADEFEFCCF8096A
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 14-53 | Polar residues | ||||
Sequence: VPGVNKTQTTEKTKPESGSSLSAVTKLSKPGTSASLLKTK | ||||||
Compositional bias | 73-119 | Polar residues | ||||
Sequence: GVKAKKSTCASTVSSTTGTTMSTLENKPRTVAGSTARRSTSSGTKES | ||||||
Compositional bias | 120-134 | Basic and acidic residues | ||||
Sequence: SSSRERIRDRSRLSQ | ||||||
Compositional bias | 136-153 | Polar residues | ||||
Sequence: KKLPLAGQGSNDTVLAKR | ||||||
Compositional bias | 154-176 | Basic and acidic residues | ||||
Sequence: SRSRTNPESDIRMSKSKSDNQIS | ||||||
Compositional bias | 299-319 | Polar residues | ||||
Sequence: ITAGNHSDGGGTLTSSVEGSA | ||||||
Compositional bias | 863-877 | Pro residues | ||||
Sequence: IPRTPLSPSPMKTPP | ||||||
Compositional bias | 967-991 | Polar residues | ||||
Sequence: LMAMGTTSPQLSLSSSPTASVTPTT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY884298 EMBL· GenBank· DDBJ | AAX84189.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |