Q2K9D7 · XGPT_RHIEC

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-425-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site98-1065-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site99Mg2+ (UniProtKB | ChEBI)
Binding site102guanine (UniProtKB | ChEBI)
Binding site102xanthine (UniProtKB | ChEBI)
Binding site102-106GMP (UniProtKB | ChEBI)
Binding site144-145GMP (UniProtKB | ChEBI)
Binding site145guanine (UniProtKB | ChEBI)
Binding site145xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • Ordered locus names
      RHE_CH01754

Organism names

Accessions

  • Primary accession
    Q2K9D7

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002610121-164Xanthine-guanine phosphoribosyltransferase

Interaction

Subunit

Homotetramer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    164
  • Mass (Da)
    18,116
  • Last updated
    2006-03-07 v1
  • Checksum
    6633F9EEE570A173
MSLPDKAFPVSWDQFHRDARALAWRLAGLDQTFKAIVCITRGGLVPAAIISRELNIRLIETVCIASYHDYVNQGDMVLLKGIAPELAENGGEGVLVVDDLTDTGKTAAQVRTMLPKAHFACVYAKPKGVPTVDTFITEVSQDTWIYFPWDMGFTYQEPIAKGAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000133
EMBL· GenBank· DDBJ
ABC90549.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp