Q2J542 · ISPD_FRACC
- Protein2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- GeneispD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids266 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity
- 2-C-methyl-D-erythritol 4-phosphate + CTP + H+ = 4-CDP-2-C-methyl-D-erythritol + diphosphate
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 26 | Transition state stabilizer | ||||
Sequence: R | ||||||
Site | 33 | Transition state stabilizer | ||||
Sequence: K | ||||||
Site | 161 | Positions MEP for the nucleophilic attack | ||||
Sequence: R | ||||||
Site | 214 | Positions MEP for the nucleophilic attack | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Frankiales > Frankiaceae > Frankia
Accessions
- Primary accessionQ2J542
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000237790 | 1-266 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | |||
Sequence: MGEGHRLPVASPRVAAIVPAAGRGERLGGGTPKALRALGGRPMLVRTVESLRRSRLVTQIVVAAPPTLVDAVAQLLGGDVYVIAGGAERVDSVRRALRAVDDDVSVVLVHDAARPLTPPELVDAVAAAVLDGHPAVIPVVPLADTVKEVDADGRVVRTPPRDGLRAVQTPQGFRRDVLSAAYALEDIAVTDDAGLVEALGVPVTTIPGAQEAFKVTRPADLVLAEALLARCDPADDARSAEARSAEARSEEPQFAGARSTDARSGG |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 234-248 | Basic and acidic residues | ||||
Sequence: ADDARSAEARSAEAR | ||||||
Region | 234-266 | Disordered | ||||
Sequence: ADDARSAEARSAEARSEEPQFAGARSTDARSGG |
Sequence similarities
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length266
- Mass (Da)27,498
- Last updated2006-03-07 v1
- Checksum7BB80635E9F23974
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 234-248 | Basic and acidic residues | ||||
Sequence: ADDARSAEARSAEAR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000249 EMBL· GenBank· DDBJ | ABD13600.1 EMBL· GenBank· DDBJ | Genomic DNA |