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Q2I3G4 · NU5M_ELEMA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processmitochondrial respiratory chain complex I assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 5

Gene names

    • Name
      MT-ND5
    • Synonyms
      MTND5, NADH5, ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Afrotheria > Proboscidea > Elephantidae > Elephas

Accessions

  • Primary accession
    Q2I3G4

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane38-58Helical
Transmembrane87-107Helical
Transmembrane124-144Helical
Transmembrane180-200Helical
Transmembrane216-236Helical
Transmembrane244-264Helical
Transmembrane276-296Helical
Transmembrane304-323Helical
Transmembrane328-350Helical
Transmembrane369-389Helical
Transmembrane404-424Helical
Transmembrane460-480Helical
Transmembrane483-503Helical
Transmembrane586-606Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002328541-606NADH-ubiquinone oxidoreductase chain 5

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    68,253
  • Last updated
    2006-04-18 v2
  • MD5 Checksum
    DC17CF5E788694782F5BAFA7CA8803FF
MKVINLIPTLTLTSLIILTLPITMTLLQNNKTNCFLYITKMAVTCAFAISLIPTLLFLQSNQEAYISNWHWMTIQTLKLSLSFKLDFFSLTFMPIALFITWSIMEFSLWYMHSDPHINRFFKYLLLFLITMLILVSANNLLQLFMGWEGVGIMSFLLISWWHGRTDANTAALQAMLYNRIGDMGFIMMMAWFIIHLNSWEFQQIFLTNPKNTTLPLLGLLLASAGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVMAGVFTLIRFYPLMENNLTIQTSTLCLGAITTLFTAICALTQNDIKKIIALSTSSQLGLMMVTIGINQPHLAFTHMCTHAFFKAMLFLSSGSIIHNLDNEQDIRKMGGLYKTMPITSTAIIIGSLALTGMPFLTGFYSKDPIIETANMSYINTWALLITLIAVSMTASYSTRIIFFALLGQPRYPTLIQVNENNPYLINPIKRLILGSIFMGFFISMNTIPHTTPQMTMPPHLKFMALAVTLLGFTVATELNNMTHNLTFKQPSRMHTFSTTLGYYPTTTHRILPYLSLTMSQNLATTIMDSIWLEKMIPKNLTTMQKTAASLVSNQKGLMKLYFLSFLLSITLGLLITL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ316068
EMBL· GenBank· DDBJ
ABC17901.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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