Q2HR71 · VIRF2_HHV8P

Function

function

DNA-binding transcription factor that plays a role in the modulation of host immune response (PubMed:26537687, PubMed:31059555).
Acts by interacting with host EIF2AK2/PKR and inhibiting its activation. In turn, EIF2AK2/PKR substrates including EIF2S1 or histone H2A are not phosphorylated (PubMed:11160738).
Inhibits type I interferon signaling by targeting host IRF3 during viral reactivation from latency (PubMed:11160738, PubMed:21697347).
Attenuates the transcriptional activity of host FOXO3 via activation of the AKT1 signaling pathway, inhibiting FOXO3-mediated apoptosis (PubMed:26797279).
Suppresses also the expression of viral early lytic genes in both newly infected and reactivated infected host cells allowing regulation of viral life cycle by harnessing the interferon pathway. Mechanistically, promotes host PML bodies formation as well as host antiviral restriction factors IFIT1-3 expression leading to inhibition of viral early lytic proteins (PubMed:31059555).
Regulates also host TRAF3 and TRAF6 ubiquitination by interacting with USP7 deubiquitinase thereby influencing TRAF3/6-mediated signal transduction (PubMed:31666375).

Features

Showing features for dna binding.

168050100150200250300350400450500550600650
TypeIDPosition(s)Description
DNA binding7-103IRF tryptophan pentad repeat

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular Functionprotein serine/threonine kinase inhibitor activity
Molecular Functiontranscription cis-regulatory region binding
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processsymbiont-mediated suppression of host PKR/eIFalpha signaling
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Viral IRF2-like protein
  • Short names
    vIRF-2

Gene names

    • Name
      vIRF-2

Organism names

Accessions

  • Primary accession
    Q2HR71
  • Secondary accessions
    • D0UZS4

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis82About 50% loss of transcriptional regulation and DNA-binding.
Mutagenesis85About 50% loss of transcriptional regulation and DNA-binding.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004237741-680Viral IRF2-like protein

Interaction

Subunit

Interacts with host EIF2AK2/PKR (PubMed:11160738).
Interacts with host USP7 (PubMed:31666375).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q2HR71EIF2AK2 P195252EBI-8876177, EBI-640775

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region156-201Disordered
Compositional bias172-191Polar residues
Region220-257Disordered
Compositional bias226-254Polar residues
Region343-365Disordered
Compositional bias346-365Polar residues
Region403-423Disordered

Sequence similarities

Belongs to the IRF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    680
  • Mass (Da)
    75,090
  • Last updated
    2006-03-21 v1
  • Checksum
    0FBC22C8F51F3084
MPRYTESEWLTDFIIDALDSGRFWGVGWLDEQKRIFTVPGRNRRERMPEGFDDFYEAFLEERRRHGLPEIPETETGLGCFGRLLRTANRARQERPFTIYKGKMKLNRWIMTPRPYKGCEGCLVYLTQEPAMKNMLKALFGIYPHDDKHREKALRRSLRKKAQREAARKQAAAVATPTTSSAAEVSSRSQSEDTESSDSENELWVGAQGFVGRDMHSLFFEEPEPSGFGSSGQSSSLLAPDSPRPSTSQVQGPLHVHTPTDLCLPTGGLPSPVIFPHETQGLLAPPAGQSQTPFSPEGPVPSHVSGLDDCLPMVDHIEGCLLDLLSDVGQELPDLGDLGELLCETASPQGPMQSEGGEEGSTESVSVLPATHPLESSAPGASVMGSGQELPDLGDLSELLCETASPQGPMQSEGGEEGSTESVSVLPATHPLESSAPGASVMGSSFQASDNVDDFIDCIPPLCRDDRDVEDQEKADQTFYWYGSDMRPKVLTATQSVAAYLSKKQAIYKVGDKLVPLVVEVYYFGEKVKTHFDLTGGIVICSQVPEASPEHICQTVPPYKCLLPRTAHCSVDANRTLEQTLDRFSMGVVAIGTNMGIFLKGLLEYPAYFVGNASRRRIGKCRPLSHRHEIQQAFDVERHNREPEGSRYASLFLGRRPSPEYDWDHYPVILHIYLAPFYHRD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias172-191Polar residues
Compositional bias226-254Polar residues
Compositional bias346-365Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF148805
EMBL· GenBank· DDBJ
ABD28912.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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