Q2HJ54 · PIPNA_BOVIN
- ProteinPhosphatidylinositol transfer protein alpha isoform
- GenePITPNA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids270 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes (PubMed:7654206).
Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity).
Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions (By similarity).
Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3 (By similarity).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)This reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 58 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 60 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 85 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 89 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 96 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 194 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | phosphatidylcholine binding | |
Molecular Function | phosphatidylcholine transfer activity | |
Molecular Function | phosphatidylcholine transporter activity | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | phosphatidylinositol transfer activity |
Keywords
- Biological process
- Ligand
Chemistry
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol transfer protein alpha isoform
- Short namesPI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ2HJ54
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for initiator methionine, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000269200 | 2-270 | Phosphatidylinositol transfer protein alpha isoform | |||
Sequence: VLLKEYRVILPVSVEEYQVGQLYSVAEASKNETGGGEGVEVLVNEPYEKDGEKGQYTHKIYHLQSKVPTFVRMLAPEGALNIHEKAWNAYPYCRTVITNEYMKEDFLIKIETWHKPDLGTLENVHKLEPEAWKHVEVIYIDIADRSQVLSKDYKAEEDPAKYKSIKTGRGPLGPNWKQELVNQKDCPYMCAYKLVTVKFKWWGLQNKVENFIHKQERRLFTNFHRQLFCWLDKWVDLTMDDIRRMEDETKRQLDEMRQKDPVKGMTADD | ||||||
Modified residue | 215 | N6-acetyllysine | ||||
Sequence: K |
Post-translational modification
Phosphorylated by PKC in a calcium and phosphatidylserine-dependent manner.
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)31,849
- Last updated2007-01-23 v3
- ChecksumFFE53A8F4D9F87CD
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAF6ZG86 | A0AAF6ZG86_BOVIN | PITPNA | 264 | ||
A0A3Q1MUH4 | A0A3Q1MUH4_BOVIN | PITPNA | 306 | ||
A0AAA9TQ15 | A0AAA9TQ15_BOVIN | PITPNA | 134 | ||
A0AAA9SCJ7 | A0AAA9SCJ7_BOVIN | PITPNA | 109 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC113306 EMBL· GenBank· DDBJ | AAI13307.1 EMBL· GenBank· DDBJ | mRNA |