Q2GHW6 · Q2GHW6_EHRCR

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site10Nucleophile
Binding site244[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site293Mg2+ (UniProtKB | ChEBI)
Binding site355Mg2+ (UniProtKB | ChEBI)
Binding site356Mg2+ (UniProtKB | ChEBI)
Binding site392[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site448[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site451[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • Ordered locus names
      ECH_0139

Organism names

Accessions

  • Primary accession
    Q2GHW6

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-227Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    462
  • Mass (Da)
    51,026
  • Last updated
    2006-03-21 v1
  • Checksum
    955577165CA9A45A
MQFNEIYEECGVFAIQNNNCAAINCILGLHALQHRGQESFGIVTSEDNKLHFHYSNEQVNSIFNQQSKIDSLLGNTAIGHIRYSTSGSKVGVQPITLDCKFGKLAIAHNGNLTNAAQIRKSLTERGCIFSSDIDTEVIAHLIAINTENTLLDNVINALKTIKGAYSLVILINGTIICCRDPAGIRPLVLGMLDNSYIVASETCALDIVGAQFIRDVLPGEFITIDQGNTLTSSFPFKKQKSSFCIFEYVYFARPDSIIDNKSIYEIRKNIGKELAIENPIPKDTHMIVPVPDSGVPAALGFAEYTKIPFEFGIIRNHYIGRTFIQPNDHIRSMGVKLKHNANSSILKDKVIVLIDDSLVRGTTLKSIITLLHKAGVQQIHLRISSPPTINSCFYGIDTPEESKLIANRLSQLEIKNALGCDSLHFLSIDGLYKAICNTKRNNSIPQYCDACFTGDYPIGKIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000236
EMBL· GenBank· DDBJ
ABD45246.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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