Q2GHW1 · DAPE_EHRCR

Function

function

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site71Zn2+ 1 (UniProtKB | ChEBI)
Active site73
Binding site104Zn2+ 1 (UniProtKB | ChEBI)
Binding site104Zn2+ 2 (UniProtKB | ChEBI)
Active site136Proton acceptor
Binding site137Zn2+ 2 (UniProtKB | ChEBI)
Binding site166Zn2+ 1 (UniProtKB | ChEBI)
Binding site351Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalt ion binding
Molecular Functionsuccinyl-diaminopimelate desuccinylase activity
Molecular Functionzinc ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinyl-diaminopimelate desuccinylase
  • EC number
  • Short names
    SDAP desuccinylase
  • Alternative names
    • N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase

Gene names

    • Name
      dapE
    • Ordered locus names
      ECH_0144

Organism names

Accessions

  • Primary accession
    Q2GHW1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003755451-381Succinyl-diaminopimelate desuccinylase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M20A family. DapE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    381
  • Mass (Da)
    41,816
  • Last updated
    2006-03-21 v1
  • Checksum
    2949DCA71F3967B4
MAIDPVILSQELISFPSITPTDNGAIDFLSNTLSQYGFTCNVLTFGNDEVQVCNLYAQLGNGHPNLCFAGHTDVVPTGDLEKWKFDPFSGHIEDNILYGRGAVDMKSAICAFIAAVSRIDFNQVNGAISLMISGDEEGNHFKYGTPAILKWLTDNNKKIDYCLVGEPTSKSSVGDTIKIGRRGSINFKIVCNGVQGHVAYPHLAQNPINDMINILHKINNTVLDEGNEYFQPSNCEITSVDVGNTANNVIPGTVTAHLNIRYNNIHTSESLFNIINNICAETTQKYQIFTSLSGDPFINYPDKYSDMLSAAIKKTTGETAVISTSGGTSDARFIKDFCPVIELGLKNDTAHKINENTSVDDINKLANIYEEFIKQFFNISQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000236
EMBL· GenBank· DDBJ
ABD45523.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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