Q2GHG8 · CTAA_EHRCR

Function

function

Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site262Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site317Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Biological Processheme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme A synthase
  • EC number
  • Short names
    HAS
  • Alternative names
    • Cytochrome aa3-controlling protein

Gene names

    • Name
      ctaA
    • Ordered locus names
      ECH_0294

Organism names

Accessions

  • Primary accession
    Q2GHG8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane14-34Helical
Transmembrane95-115Helical
Transmembrane125-145Helical
Transmembrane162-182Helical
Transmembrane198-218Helical
Transmembrane260-280Helical
Transmembrane287-307Helical
Transmembrane311-331Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003490311-344Heme A synthase

Interaction

Subunit

Interacts with CtaB.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the COX15/CtaA family. Type 2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    39,512
  • Last updated
    2006-03-21 v1
  • Checksum
    BA66FE56E06A7553
MKIASDNREVCVGVKIWLCICCIGILLMVLVGGITRLTHSGLSITEWNPVIGVFPPIGERAWIREKIKYMATPEFKYLNFNITLRGFRKLYLIEYFHRLLGRIVGLTFLIPFLYFTYKKKLHRNLIINFIVICLLILFQGVVGWFMVKSGLIDRPHVSHYKLTAHLLLALLIFYLLWRQFLLSTISKVTYNIKVNGTLIFSVISVLIVTQITFGSLVAGLNAGLLDKTIPFLAGKLMLEDLLFIKPLWYNIFENPVTVQFIHELIATLIFLVVIITLLILRLNLFPAYLLLICLCLQLTLGVLTFIYNVPIVLASLHQVTAFILFAVNTYLLHYMKLSKLQYVK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000236
EMBL· GenBank· DDBJ
ABD45450.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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