Q2GHG8 · CTAA_EHRCR
- ProteinHeme A synthase
- GenectaA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids344 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Catalytic activity
- Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2This reaction proceeds in the forward direction.
Cofactor
Pathway
Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 262 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 317 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | |
Biological Process | heme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHeme A synthase
- EC number
- Short namesHAS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Anaplasmataceae > Ehrlichia
Accessions
- Primary accessionQ2GHG8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 14-34 | Helical | |||
Transmembrane | 95-115 | Helical | |||
Transmembrane | 125-145 | Helical | |||
Transmembrane | 162-182 | Helical | |||
Transmembrane | 198-218 | Helical | |||
Transmembrane | 260-280 | Helical | |||
Transmembrane | 287-307 | Helical | |||
Transmembrane | 311-331 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000349031 | 1-344 | Heme A synthase | ||
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the COX15/CtaA family. Type 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)39,512
- Last updated2006-03-21 v1
- ChecksumBA66FE56E06A7553
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000236 EMBL· GenBank· DDBJ | ABD45450.1 EMBL· GenBank· DDBJ | Genomic DNA |