Q2GH93 · Q2GH93_EHRCR

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site14-16N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site62(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site104(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site106Proton donor
Site142Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • Ordered locus names
      ECH_0370

Organism names

Accessions

  • Primary accession
    Q2GH93

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-179Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,811
  • Last updated
    2006-03-21 v1
  • Checksum
    555CA2CFE2600229
MTPLKLGILISGRGSNMQALINACAQDDFPAEVSCVISNNPKANGLLIAQKQNIKTFVVQGRPLDFDSIDSILRQHQVDLICLAGFMSIVPEGFINKWFHKIINIHPSLLPSFKGLNAQSQALKAGVKIAGCTVHYVYPEVDGGPIIVQAAVPVFSSDNLTDLSERILKMEHICYPKAVKLIALNQLQLNENLATSAELLHMFYDETI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000236
EMBL· GenBank· DDBJ
ABD44645.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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