Q2G2X2 · TARD_STAA8
- ProteinGlycerol-3-phosphate cytidylyltransferase
- GenetarD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids132 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the transfer of the cytidylyl group of CTP to sn-glycerol 3-phosphate so the activated glycerol 3-phosphate can be used for teichoic acid synthesis, via incorporation into both the linkage unit by TarB and TarF.
Catalytic activity
- CTP + H+ + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
36 μM | CTP | |||||
21 μM | glycerol 3-phosphate |
kcat is 2.6 sec-1.
Pathway
Cell wall biogenesis; poly(ribitol phosphate) teichoic acid biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-10 | CTP (UniProtKB | ChEBI) | ||||
Sequence: TY | ||||||
Binding site | 14-17 | CTP (UniProtKB | ChEBI) | ||||
Sequence: HYGH | ||||||
Binding site | 44 | substrate | ||||
Sequence: K | ||||||
Binding site | 46 | CTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 77 | substrate | ||||
Sequence: K | ||||||
Binding site | 113-120 | CTP (UniProtKB | ChEBI) | ||||
Sequence: RTEGISTT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glycerol-3-phosphate cytidylyltransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | cell wall organization | |
Biological Process | teichoic acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-3-phosphate cytidylyltransferase
- EC number
- Short namesGCT ; GCTase ; Gro-PCT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionQ2G2X2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000438714 | 1-132 | Glycerol-3-phosphate cytidylyltransferase | |||
Sequence: MKRVITYGTYDLLHYGHIELLRRAREMGDYLIVALSTDEFNQIKHKKSYYDYEQRKMMLESIRYVDLVIPEKGWGQKEDDVEKFDVDVFVMGHDWEGEFDFLKDKCEVIYLKRTEGISTTKIKQELYGKDAK |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length132
- Mass (Da)15,817
- Last updated2006-03-21 v1
- ChecksumAB836BA24663EF30
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000253 EMBL· GenBank· DDBJ | ABD29780.1 EMBL· GenBank· DDBJ | Genomic DNA |